Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer

Matteo De Poli, Wojciech Zawodny, Ophélie Quinonero, Mark Lorch, Simon J. Webb, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

69 Citations (Scopus)
382 Downloads (Pure)

Abstract

The dynamic properties of foldamers, synthetic molecules that mimic folded biomolecules, have mainly been explored in free solution. Here we report on the design, synthesis, and conformational behavior of photoresponsive foldamers bound in a phospholipid bilayer akin to a biological membrane phase. These molecules contain a chromophore, which can be switched between two configurations by different wavelengths of light, attached to a helical oligoamide that both promotes membrane insertion and communicates conformational change along its length. Light-induced structural changes in the chromophore are translated into global conformational changes, detected by monitoring the solid state 19F nuclear magnetic resonance signals of a remote fluorine-containing residue located 1 to 2 nm away. The behavior of the foldamers in the membrane phase is similar to that of analogous compounds in organic solvents.
Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalScience
Volume352
Issue number6285
Early online date31 Mar 2016
DOIs
Publication statusPublished - 29 Apr 2016

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