Conjunctive functionalization of vinyl boronate complexes with electrophiles: A diastereoselective three-component coupling

Roly J. Armstrong; Christopher Sandford; Cristina García-Ruiz; Varinder K. Aggarwal

doi:10.1039/c7cc01671a

Conjunctive functionalization of vinyl boronate complexes with electrophiles: A diastereoselective three-component coupling

Roly J. Armstrong, Christopher Sandford, Cristina García-Ruiz, Varinder K. Aggarwal^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

A method for the conjunctive functionalization of vinyl boronate complexes with electrophiles is described. The overall process represents a three-component coupling between a vinyl boronic ester, carbon nucleophile and an electrophile, thus affording complex multifunctionalized products from simple starting materials. The diastereoselectivity (syn or anti) of this process is strongly dependent upon the nature of the electrophile.

Original language	English
Pages (from-to)	4922-4925
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	36
Early online date	20 Apr 2017
DOIs	https://doi.org/10.1039/c7cc01671a
Publication status	Published - 20 Apr 2017

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3-month Core Capability for Chemistry Research
Crosby, J.
1/01/13 → 1/04/13
Project: Research
Changing the Synthesis Landscape with Boron at the Helm: from Chiral Organometallics to Assembly Line Synthesis
Aggarwal, V. K.
14/05/12 → 13/01/18
Project: Research

Cite this

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title = "Conjunctive functionalization of vinyl boronate complexes with electrophiles: A diastereoselective three-component coupling",

abstract = "A method for the conjunctive functionalization of vinyl boronate complexes with electrophiles is described. The overall process represents a three-component coupling between a vinyl boronic ester, carbon nucleophile and an electrophile, thus affording complex multifunctionalized products from simple starting materials. The diastereoselectivity (syn or anti) of this process is strongly dependent upon the nature of the electrophile.",

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AU - Aggarwal, Varinder K.

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N2 - A method for the conjunctive functionalization of vinyl boronate complexes with electrophiles is described. The overall process represents a three-component coupling between a vinyl boronic ester, carbon nucleophile and an electrophile, thus affording complex multifunctionalized products from simple starting materials. The diastereoselectivity (syn or anti) of this process is strongly dependent upon the nature of the electrophile.

AB - A method for the conjunctive functionalization of vinyl boronate complexes with electrophiles is described. The overall process represents a three-component coupling between a vinyl boronic ester, carbon nucleophile and an electrophile, thus affording complex multifunctionalized products from simple starting materials. The diastereoselectivity (syn or anti) of this process is strongly dependent upon the nature of the electrophile.

U2 - 10.1039/c7cc01671a

DO - 10.1039/c7cc01671a

M3 - Article (Academic Journal)

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JO - Chemical Communications

JF - Chemical Communications

IS - 36

ER -

Conjunctive functionalization of vinyl boronate complexes with electrophiles: A diastereoselective three-component coupling

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3-month Core Capability for Chemistry Research

Changing the Synthesis Landscape with Boron at the Helm: from Chiral Organometallics to Assembly Line Synthesis

Cite this