Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness

Mélanie Boly, Rosalyn Moran, Michael Murphy, Pierre Boveroux, Marie-Aurélie Bruno, Quentin Noirhomme, Didier Ledoux, Vincent Bonhomme, Jean-François Brichant, Giulio Tononi, Steven Laureys, Karl Friston

Research output: Contribution to journalArticle (Academic Journal)peer-review

182 Citations (Scopus)

Abstract

The mechanisms underlying anesthesia-induced loss of consciousness remain a matter of debate. Recent electrophysiological reports suggest that while initial propofol infusion provokes an increase in fast rhythms (from beta to gamma range), slow activity (from delta to alpha range) rises selectively during loss of consciousness. Dynamic causal modeling was used to investigate the neural mechanisms mediating these changes in spectral power in humans. We analyzed source-reconstructed data from frontal and parietal cortices during normal wakefulness, propofol-induced mild sedation, and loss of consciousness. Bayesian model selection revealed that the best model for explaining spectral changes across the three states involved changes in corticothalamic interactions. Compared with wakefulness, mild sedation was accounted for by an increase in thalamic excitability, which did not further increase during loss of consciousness. In contrast, loss of consciousness per se was accompanied by a decrease in backward corticocortical connectivity from frontal to parietal cortices, while thalamocortical connectivity remained unchanged. These results emphasize the importance of recurrent corticocortical communication in the maintenance of consciousness and suggest a direct effect of propofol on cortical dynamics.

Original languageEnglish
Pages (from-to)7082-90
Number of pages9
JournalJournal of Neuroscience
Volume32
Issue number20
DOIs
Publication statusPublished - 16 May 2012

Keywords

  • Adult
  • Anesthetics, Intravenous
  • Bayes Theorem
  • Brain Waves
  • Conscious Sedation
  • Electroencephalography
  • Female
  • Frontal Lobe
  • Humans
  • Hypnotics and Sedatives
  • Male
  • Models, Neurological
  • Neural Pathways
  • Parietal Lobe
  • Propofol
  • Thalamus
  • Unconsciousness
  • Wakefulness

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