Projects per year
Tetrahydroisoquinolines and tetrahydrobenzazepines were prepared by acid-promoted ring contraction of cyclic ureas, which were themselves formed by ring expansion of indolines and tetrahydroquinolines. The consequent overall one-carbon insertion reaction gives these 6- and 7-membered heterocyclic scaffolds in three steps from readily available precursors. Other ring sizes may be formed by an alternative elimination reaction of bicyclic structures. Scalability of the method was demonstrated by operating it in a flow system.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Early online date||14 Mar 2018|
|Publication status||Published - 14 May 2018|
- BCS and TECS CDTs
- ring contraction
FingerprintDive into the research topics of 'Consecutive Ring Expansion and Contraction for the Synthesis of 1-Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors'. Together they form a unique fingerprint.
- 1 Finished
alpha-Arylation and alpha-Vinylation of Enolates: New Reactivity from the Urea Linkage.
1/07/15 → 31/05/18
Professor Jonathan Clayden
- School of Chemistry - Professor of Chemistry