TY - JOUR
T1 - Consensus-based recommendations for the management of uveitis associated with juvenile idiopathic arthritis
T2 - the SHARE initiative
AU - Constantin, Tamas
AU - Foeldvari, Ivan
AU - Anton, Jordi
AU - De Boer, Joke
AU - Czitrom-Guillaume, Severine
AU - Edelsten, Clive
AU - Gepstein, Raz
AU - Heiligenhaus, Arnd
AU - Pilkington, Clarissa A.
AU - Simonini, Gabriele
AU - Uziel, Yosef
AU - Vastert, Sebastian J.
AU - Wulffraat, Nico M.
AU - Haasnoot, Anne Mieke
AU - Walscheid, Karoline
AU - Pálinkás, Annamária
AU - Pattani, Reshma
AU - Györgyi, Zoltán
AU - Kozma, Richárd
AU - Boom, Victor
AU - Ponyi, Andrea
AU - Ravelli, Angelo
AU - Ramanan, Athimalaipet V.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - BACKGROUND: In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and uveitis is possibly its most devastating extra-articular manifestation. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment practices differ widely, within and between nations.OBJECTIVES: To provide recommendations for the diagnosis and treatment of JIA-associated uveitis.METHODS: Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of nine experienced paediatric rheumatologists and three experts in ophthalmology from Europe. Recommendations derived from a validated systematic literature review were evaluated by an Expert Committee and subsequently discussed at two consensus meetings using nominal group techniques. Recommendations were accepted if >80% agreement was reached (including all three ophthalmologists).RESULTS: In total, 22 recommendations were accepted (with >80% agreement among experts): 3 on diagnosis, 5 on disease activity measurements, 12 on treatment and 2 on future recommendations.CONCLUSIONS: The SHARE initiative aims to identify best practices for treatment of patients suffering from JIA-associated uveitis. Within this remit, recommendations for the diagnosis and treatment of JIA-associated uveitis have been formulated by an evidence-informed consensus process to suggest a standard of care for JIA-associated uveitis patients throughout Europe.
AB - BACKGROUND: In 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in children and uveitis is possibly its most devastating extra-articular manifestation. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment practices differ widely, within and between nations.OBJECTIVES: To provide recommendations for the diagnosis and treatment of JIA-associated uveitis.METHODS: Recommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of nine experienced paediatric rheumatologists and three experts in ophthalmology from Europe. Recommendations derived from a validated systematic literature review were evaluated by an Expert Committee and subsequently discussed at two consensus meetings using nominal group techniques. Recommendations were accepted if >80% agreement was reached (including all three ophthalmologists).RESULTS: In total, 22 recommendations were accepted (with >80% agreement among experts): 3 on diagnosis, 5 on disease activity measurements, 12 on treatment and 2 on future recommendations.CONCLUSIONS: The SHARE initiative aims to identify best practices for treatment of patients suffering from JIA-associated uveitis. Within this remit, recommendations for the diagnosis and treatment of JIA-associated uveitis have been formulated by an evidence-informed consensus process to suggest a standard of care for JIA-associated uveitis patients throughout Europe.
KW - juvenile idiopathic arthritis
KW - methotrexate
KW - Tnf-alpha
UR - http://www.scopus.com/inward/record.url?scp=85049005157&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2018-213131
DO - 10.1136/annrheumdis-2018-213131
M3 - Article (Academic Journal)
C2 - 29592918
SN - 0003-4967
VL - 77
SP - 1107
EP - 1117
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 8
ER -