Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project

Anushka Aggarwal; Tanya Chandra; Shiri Keret; John D Pauling; Ejaz A Shamim; Francesco Bonella; Fredrick W Miller; Andrew Mammen; Gianluca Sambataro; Teerin Liewluck; Anthony P Fernandez; Elena Bartoloni; Samuel Katsuyuki Shinjo; Santos Castañeda; Victoria Werth; Mazen M Dimachkie; Yasuhiro Katsumata; Raquel Campanilho-Marques; Manabu Fujimoto; James B Lilleker; Albert Selva-O'Callaghan; Tahseen Mozaffar; Harsha Gunawardena; Herman Mann; Jorge Rojas Serrano; Lorenzo Cavagna; Siamak Moghadam-Kia; Chester V Oddis; Parth Ladha; Srijan Mittal; Saloni Haldule; Namratha Edpuganti; Shreya Sridhar; Rutvik Savaliya; Vanshita Batra; Rohit Aggarwal

doi:10.1093/rheumatology/keaf229

Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project

Anushka Aggarwal, Tanya Chandra, Shiri Keret, John D Pauling, Ejaz A Shamim, Francesco Bonella, Fredrick W Miller, Andrew Mammen, Gianluca Sambataro, Teerin Liewluck, Anthony P Fernandez, Elena Bartoloni, Samuel Katsuyuki Shinjo, Santos Castañeda, Victoria Werth, Mazen M Dimachkie, Yasuhiro Katsumata, Raquel Campanilho-Marques, Manabu Fujimoto, James B LillekerAlbert Selva-O'Callaghan, Tahseen Mozaffar, Harsha Gunawardena, Herman Mann, Jorge Rojas Serrano, Lorenzo Cavagna, Siamak Moghadam-Kia, Chester V Oddis, Parth Ladha, Srijan Mittal, Saloni Haldule, Namratha Edpuganti, Shreya Sridhar, Rutvik Savaliya, Vanshita Batra, Rohit Aggarwal^*

^*Corresponding author for this work

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

Abstract

Objectives:
The lack of uniform terminology and abbreviations for anti-synthetase syndrome has led to significant challenges in research and clinical practice. This study aimed to establish an international consensus on a standardized nomenclature and abbreviation among a diverse group of global myositis experts and patient representatives.

Methods:
This qualitative project was approved by the International Myositis Assessment and Clinical Studies Group (IMACS). Based on the outcomes of a literature review and preliminary survey, list of terms for nomenclature and abbreviations was finalized. Subsequently, two rounds of the Delphi survey were conducted among myositis experts and patient participants to ascertain current practices and preferences. Using Nominal Group Technique (NGT), the project steering committee developed a consensus nomenclature and abbreviation.

Results:
A total of 241 and 132 myositis experts from six continents, 35 countries and 9 specialities participated in round 1 and round 2 of the Delphi survey, respectively. The results indicated a preference for the terms anti-synthetase syndrome, antisynthetase syndrome and anti-tRNA synthetase syndrome. The abbreviations ASS, ASyS and ASSD were most used, though ASS received notable disapproval. The steering committee, including twenty-five myositis experts and three patient representatives from diverse backgrounds and geographical locations, reached a consensus on ‘anti-synthetase syndrome’ as the preferred nomenclature and ASyS as the preferred abbreviation, with 100% and 93.1% votes, respectively.

Conclusion:
The terms anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature and abbreviation in both research and clinical practice. This standardization is expected to increase consistency within the literature.

Original language	English
Pages (from-to)	4930-4936
Number of pages	7
Journal	Rheumatology
Volume	64
Issue number	9
Early online date	26 Apr 2025
DOIs	https://doi.org/10.1093/rheumatology/keaf229
Publication status	Published - 1 Sept 2025

Bibliographical note

Publisher Copyright:
© The Author(s) 2025.

Keywords

Humans
Myositis/classification
Terminology as Topic
Consensus
Delphi Technique
Amino Acyl-tRNA Synthetases/immunology

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Aggarwal, A., Chandra, T., Keret, S., Pauling, J. D., Shamim, E. A., Bonella, F., Miller, F. W., Mammen, A., Sambataro, G., Liewluck, T., Fernandez, A. P., Bartoloni, E., Shinjo, S. K., Castañeda, S., Werth, V., Dimachkie, M. M., Katsumata, Y., Campanilho-Marques, R., Fujimoto, M., ... Aggarwal, R. (2025). Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project. Rheumatology, 64(9), 4930-4936. https://doi.org/10.1093/rheumatology/keaf229

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title = "Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project",

abstract = "Objectives: The lack of uniform terminology and abbreviations for anti-synthetase syndrome has led to significant challenges in research and clinical practice. This study aimed to establish an international consensus on a standardized nomenclature and abbreviation among a diverse group of global myositis experts and patient representatives. Methods: This qualitative project was approved by the International Myositis Assessment and Clinical Studies Group (IMACS). Based on the outcomes of a literature review and preliminary survey, list of terms for nomenclature and abbreviations was finalized. Subsequently, two rounds of the Delphi survey were conducted among myositis experts and patient participants to ascertain current practices and preferences. Using Nominal Group Technique (NGT), the project steering committee developed a consensus nomenclature and abbreviation. Results: A total of 241 and 132 myositis experts from six continents, 35 countries and 9 specialities participated in round 1 and round 2 of the Delphi survey, respectively. The results indicated a preference for the terms anti-synthetase syndrome, antisynthetase syndrome and anti-tRNA synthetase syndrome. The abbreviations ASS, ASyS and ASSD were most used, though ASS received notable disapproval. The steering committee, including twenty-five myositis experts and three patient representatives from diverse backgrounds and geographical locations, reached a consensus on {\textquoteleft}anti-synthetase syndrome{\textquoteright} as the preferred nomenclature and ASyS as the preferred abbreviation, with 100\% and 93.1\% votes, respectively. Conclusion: The terms anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature and abbreviation in both research and clinical practice. This standardization is expected to increase consistency within the literature.",

keywords = "Humans, Myositis/classification, Terminology as Topic, Consensus, Delphi Technique, Amino Acyl-tRNA Synthetases/immunology",

author = "Anushka Aggarwal and Tanya Chandra and Shiri Keret and Pauling, \{John D\} and Shamim, \{Ejaz A\} and Francesco Bonella and Miller, \{Fredrick W\} and Andrew Mammen and Gianluca Sambataro and Teerin Liewluck and Fernandez, \{Anthony P\} and Elena Bartoloni and Shinjo, \{Samuel Katsuyuki\} and Santos Casta{\~n}eda and Victoria Werth and Dimachkie, \{Mazen M\} and Yasuhiro Katsumata and Raquel Campanilho-Marques and Manabu Fujimoto and Lilleker, \{James B\} and Albert Selva-O'Callaghan and Tahseen Mozaffar and Harsha Gunawardena and Herman Mann and \{Rojas Serrano\}, Jorge and Lorenzo Cavagna and Siamak Moghadam-Kia and Oddis, \{Chester V\} and Parth Ladha and Srijan Mittal and Saloni Haldule and Namratha Edpuganti and Shreya Sridhar and Rutvik Savaliya and Vanshita Batra and Rohit Aggarwal",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = sep,

day = "1",

doi = "10.1093/rheumatology/keaf229",

language = "English",

volume = "64",

pages = "4930--4936",

journal = "Rheumatology",

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Aggarwal, A, Chandra, T, Keret, S, Pauling, JD, Shamim, EA, Bonella, F, Miller, FW, Mammen, A, Sambataro, G, Liewluck, T, Fernandez, AP, Bartoloni, E, Shinjo, SK, Castañeda, S, Werth, V, Dimachkie, MM, Katsumata, Y, Campanilho-Marques, R, Fujimoto, M, Lilleker, JB, Selva-O'Callaghan, A, Mozaffar, T, Gunawardena, H, Mann, H, Rojas Serrano, J, Cavagna, L, Moghadam-Kia, S, Oddis, CV, Ladha, P, Mittal, S, Haldule, S, Edpuganti, N, Sridhar, S, Savaliya, R, Batra, V & Aggarwal, R 2025, 'Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project', Rheumatology, vol. 64, no. 9, pp. 4930-4936. https://doi.org/10.1093/rheumatology/keaf229

TY - JOUR

T1 - Consensus nomenclature and abbreviation for anti-synthetase syndrome

T2 - an IMACS project

AU - Aggarwal, Anushka

AU - Chandra, Tanya

AU - Keret, Shiri

AU - Pauling, John D

AU - Shamim, Ejaz A

AU - Bonella, Francesco

AU - Miller, Fredrick W

AU - Mammen, Andrew

AU - Sambataro, Gianluca

AU - Liewluck, Teerin

AU - Fernandez, Anthony P

AU - Bartoloni, Elena

AU - Shinjo, Samuel Katsuyuki

AU - Castañeda, Santos

AU - Werth, Victoria

AU - Dimachkie, Mazen M

AU - Katsumata, Yasuhiro

AU - Campanilho-Marques, Raquel

AU - Fujimoto, Manabu

AU - Lilleker, James B

AU - Selva-O'Callaghan, Albert

AU - Mozaffar, Tahseen

AU - Gunawardena, Harsha

AU - Mann, Herman

AU - Rojas Serrano, Jorge

AU - Cavagna, Lorenzo

AU - Moghadam-Kia, Siamak

AU - Oddis, Chester V

AU - Ladha, Parth

AU - Mittal, Srijan

AU - Haldule, Saloni

AU - Edpuganti, Namratha

AU - Sridhar, Shreya

AU - Savaliya, Rutvik

AU - Batra, Vanshita

AU - Aggarwal, Rohit

PY - 2025/9/1

Y1 - 2025/9/1

N2 - Objectives: The lack of uniform terminology and abbreviations for anti-synthetase syndrome has led to significant challenges in research and clinical practice. This study aimed to establish an international consensus on a standardized nomenclature and abbreviation among a diverse group of global myositis experts and patient representatives. Methods: This qualitative project was approved by the International Myositis Assessment and Clinical Studies Group (IMACS). Based on the outcomes of a literature review and preliminary survey, list of terms for nomenclature and abbreviations was finalized. Subsequently, two rounds of the Delphi survey were conducted among myositis experts and patient participants to ascertain current practices and preferences. Using Nominal Group Technique (NGT), the project steering committee developed a consensus nomenclature and abbreviation. Results: A total of 241 and 132 myositis experts from six continents, 35 countries and 9 specialities participated in round 1 and round 2 of the Delphi survey, respectively. The results indicated a preference for the terms anti-synthetase syndrome, antisynthetase syndrome and anti-tRNA synthetase syndrome. The abbreviations ASS, ASyS and ASSD were most used, though ASS received notable disapproval. The steering committee, including twenty-five myositis experts and three patient representatives from diverse backgrounds and geographical locations, reached a consensus on ‘anti-synthetase syndrome’ as the preferred nomenclature and ASyS as the preferred abbreviation, with 100% and 93.1% votes, respectively. Conclusion: The terms anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature and abbreviation in both research and clinical practice. This standardization is expected to increase consistency within the literature.

AB - Objectives: The lack of uniform terminology and abbreviations for anti-synthetase syndrome has led to significant challenges in research and clinical practice. This study aimed to establish an international consensus on a standardized nomenclature and abbreviation among a diverse group of global myositis experts and patient representatives. Methods: This qualitative project was approved by the International Myositis Assessment and Clinical Studies Group (IMACS). Based on the outcomes of a literature review and preliminary survey, list of terms for nomenclature and abbreviations was finalized. Subsequently, two rounds of the Delphi survey were conducted among myositis experts and patient participants to ascertain current practices and preferences. Using Nominal Group Technique (NGT), the project steering committee developed a consensus nomenclature and abbreviation. Results: A total of 241 and 132 myositis experts from six continents, 35 countries and 9 specialities participated in round 1 and round 2 of the Delphi survey, respectively. The results indicated a preference for the terms anti-synthetase syndrome, antisynthetase syndrome and anti-tRNA synthetase syndrome. The abbreviations ASS, ASyS and ASSD were most used, though ASS received notable disapproval. The steering committee, including twenty-five myositis experts and three patient representatives from diverse backgrounds and geographical locations, reached a consensus on ‘anti-synthetase syndrome’ as the preferred nomenclature and ASyS as the preferred abbreviation, with 100% and 93.1% votes, respectively. Conclusion: The terms anti-synthetase syndrome and ASyS should be adopted as the standard nomenclature and abbreviation in both research and clinical practice. This standardization is expected to increase consistency within the literature.

KW - Humans

KW - Myositis/classification

KW - Terminology as Topic

KW - Consensus

KW - Delphi Technique

KW - Amino Acyl-tRNA Synthetases/immunology

U2 - 10.1093/rheumatology/keaf229

DO - 10.1093/rheumatology/keaf229

M3 - Article (Academic Journal)

C2 - 40286313

SN - 1462-0324

VL - 64

SP - 4930

EP - 4936

JO - Rheumatology

JF - Rheumatology

IS - 9

ER -

Consensus nomenclature and abbreviation for anti-synthetase syndrome: an IMACS project

Abstract

Bibliographical note

Keywords

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