Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

Jonathan Clayden*, Christopher C. Stimson, Martine Keenan

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Abstract

Directed metallation and sulfinylation yields sulfoxides which undergo ipso nucleophilic aromatic substitution with tertiary and secondary alkyllithiums, giving aromatic rings bearing alkyl groups generally incompatible with directed metallation methods and with regioselectivity complementary with classical Friedel-Crafts substitution.

Original languageEnglish
Pages (from-to)1393-1394
Number of pages2
JournalChemical Communications
Issue number13
Early online date21 Feb 2006
DOIs
Publication statusPublished - 7 Apr 2006

Fingerprint Dive into the research topics of 'Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation'. Together they form a unique fingerprint.

  • Cite this