Projects per year
Abstract
Maternal smoking and micronutrient intake during pregnancy are two strong biological candidates for impacting the developing epigenome. The extent to which DNA methylation in offspring is modified by these intrauterine exposures has not been presented in parallel. In this review, we summarize human studies which have investigated genome-wide DNA methylation in the offspring in relation to maternal smoking and one-carbon micronutrient exposure during pregnancy. We contrast the primarily independent efforts for these two categories of exposure, and potential explanations for these differences. We emphasize methodological considerations such as power to detect methylation
signals, exposure assessment, control of sources of variability, causal inference and the role of observed methylation changes in mediating downstream outcomes in the offspring.
signals, exposure assessment, control of sources of variability, causal inference and the role of observed methylation changes in mediating downstream outcomes in the offspring.
Original language | English |
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Pages (from-to) | 329-345 |
Number of pages | 17 |
Journal | Epigenomics |
Volume | 9 |
Issue number | 3 |
Early online date | 17 Feb 2017 |
DOIs | |
Publication status | Published - Mar 2017 |
Research Groups and Themes
- ICEP
Keywords
- Epigenome-wide association study (EWAS)
- DNA methylation
- maternal smoking
- micronutrients
- one-carbon metabolism
- folate
- epigenetic epidemiology
Fingerprint
Dive into the research topics of 'Contrasting the effects of intra-uterine smoking and one-carbon micronutrient exposures on offspring DNA methylation'. Together they form a unique fingerprint.Projects
- 2 Finished
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(IEU) Epigenetics: Environment, Embodiment & Equality (E4)
Relton, C. L. (Principal Investigator)
1/01/16 → 31/12/19
Project: Research
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MRC UoB UNITE Unit - Programme 2
Relton, C. L. (Principal Investigator) & Relton, C. L. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research