Contribution to variability in response to opioids

GW Hanks, CM Reid

Research output: Contribution to journalArticle (Academic Journal)peer-review

43 Citations (Scopus)


Opioids are the oldest and most effective agents for the short- and long-term control of severe pain, particularly chronic cancer pain palliation. However, morphine and other opioids display wide variations in pharmacological efficacy and tolerability, and a significant number of patients are unable to achieve adequately controlled pain at doses that do not produce intolerable adverse effects. This article reviews factors that affect the efficacy and tolerability of opioid analgesics and clinical strategies for successful pain mangement.
Translated title of the contributionContribution to variability in response to opioids
Original languageEnglish
Pages (from-to)145 - 152
Number of pages7
JournalSupportive Care in Cancer
Publication statusPublished - Mar 2005

Bibliographical note

Publisher: Springer-Verlag


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