Contributions of Mammalian Chimeras to Pluripotent Stem Cell Research

Victoria L Mascetti, Roger A Pedersen

Research output: Contribution to journalReview article (Academic Journal)peer-review

Abstract

Chimeras are widely acknowledged as the gold standard for assessing stem cell pluripotency, based on their capacity to test donor cell lineage potential in the context of an organized, normally developing tissue. Experimental chimeras provide key insights into mammalian developmental mechanisms and offer a resource for interrogating the fate potential of various pluripotent stem cell states. We highlight the applications and current limitations presented by intra- and inter-species chimeras and consider their future contribution to the stem cell field. Despite the technical and ethical demands of experimental chimeras, including human-interspecies chimeras, they are a provocative resource for achieving regenerative medicine goals.

Original languageEnglish
Pages (from-to)163-175
Number of pages13
JournalCell Stem Cell
Volume19
Issue number2
DOIs
Publication statusPublished - 4 Aug 2016

Bibliographical note

Copyright © 2016 Elsevier Inc. All rights reserved.
proxy date of acceptance added to output record.

Keywords

  • Animals
  • Cell Lineage
  • Chimera/metabolism
  • Embryo, Mammalian/cytology
  • Humans
  • Pluripotent Stem Cells/cytology
  • Species Specificity
  • Stem Cell Research

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