Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

Nephtali Marina, Ana Paula Abdala, Alla Korsak, Annabel E Simms, Andrew M Allen, Julian F R Paton, Alexander V Gourine

Research output: Contribution to journalArticle (Academic Journal)

54 Citations (Scopus)
14 Downloads (Pure)

Abstract

Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses.
Original languageEnglish
Pages (from-to)703-10
Number of pages8
JournalCardiovascular Research
Volume91
Issue number4
DOIs
Publication statusPublished - 2011

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