Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

Nephtali Marina; Ana Paula  Abdala; Alla Korsak; Annabel E Simms; Andrew M Allen; Julian F R Paton; Alexander V Gourine

doi:10.1093/cvr/cvr128

Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

Nephtali Marina, Ana Paula Abdala, Alla Korsak, Annabel E Simms, Andrew M Allen, Julian F R Paton, Alexander V Gourine

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Abstract

Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses.

Original language	English
Pages (from-to)	703-10
Number of pages	8
Journal	Cardiovascular Research
Volume	91
Issue number	4
DOIs	https://doi.org/10.1093/cvr/cvr128
Publication status	Published - 2011

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title = "Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata",

abstract = "Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses.",

author = "Nephtali Marina and Abdala, {Ana Paula} and Alla Korsak and Simms, {Annabel E} and Allen, {Andrew M} and Paton, {Julian F R} and Gourine, {Alexander V}",

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AU - Marina, Nephtali

AU - Abdala, Ana Paula

AU - Korsak, Alla

AU - Simms, Annabel E

AU - Allen, Andrew M

AU - Paton, Julian F R

AU - Gourine, Alexander V

PY - 2011

Y1 - 2011

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AB - Increased sympathetic tone in obstructive sleep apnoea results from recurrent episodes of systemic hypoxia and hypercapnia and might be an important contributor to the development of cardiovascular disease. In this study, we re-evaluated the role of a specific population of sympathoexcitatory catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata in the control of sympathetic vasomotor tone, arterial blood pressure, and hypercapnia-evoked sympathetic and cardiovascular responses.

U2 - 10.1093/cvr/cvr128

DO - 10.1093/cvr/cvr128

M3 - Article (Academic Journal)

C2 - 21543384

SN - 0008-6363

VL - 91

SP - 703

EP - 710

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 4

ER -

Control of sympathetic vasomotor tone by catecholaminergic C1 neurones of the rostral ventrolateral medulla oblongata

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