Controlled delivery of ciprofloxacin using zirconium-based MOFs and poly-caprolactone composites

Saynab F. Aden, Lila A.M. Mahmoud, Evdokiya H. Ivanovska, Lui R. Terry, Valeska P. Ting, Maria G. Katsikogianni, Sanjit Nayak*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)

Abstract

Highlights

•Two Zr-based MOFs were loaded with ciprofloxacin (CIP) using post-synthetic method
•Biodegradable PCL-MOF composites were prepared with CIP loaded MOFs
•The PCL-MOF composites showed controlled and sustained release of CIP
•The MOFs and composites were found highly efficient against E. coli than S. aureus



Abstract

With antimicrobial resistance (AMR) increasing at an alarming rate, there is a need to develop better antibiotic delivery platforms at the point of need, to reduce over-exposure to antibiotics that are delivered systemically. Recent studies have suggested the use of metal-organic frameworks (MOFs) as potential vehicles for controlled and efficient delivery of various active pharmaceutical ingredients (APIs). Development of MOF-polymer composite materials can assist in the development of medical devices that can deliver APIs to local sites in a targeted approach. This study reports the encapsulation of a widely used antibiotic - ciprofloxacin (CIP) - into two Zr-based MOFs (UiO-66 and UiO-66-NH2) and their subsequent integration into a biodegradable polymer; polycaprolactone (PCL), via solvent casting, to obtain a PCL-MOF composite membrane. The MOFs and PCL-MOF composites were characterised by Fourier-transformed infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The results demonstrated that the structural integrity of the pristine MOFs was maintained after drug loading and incorporation into the PCL membranes. The ciprofloxacin release was studied using ultraviolet–visible (UV–Vis) spectroscopy, and the results showed that the PCL-MOF composites had a more controlled drug release profile compared to the MOF alone, when monitored for seven days in phosphate buffered saline (PBS) and accelerated ageing (AA) release media. In addition, release studies showed pH-dependence with faster release of ciprofloxacin at both acidic and basic conditions. Antimicrobial assay showed excellent efficacy for both CIP-loaded MOFs and their PCL composites against S. aureus and E. coli, a Gram-negative and Gram-positive bacterium, respectively, with inhibition zone as high as >50 mm against E. coli for UiO-66-NH2-CIP, indicating their potential applications in purpose-specific medical devices.
Original languageEnglish
Article number104894
Number of pages12
JournalJournal of Drug Delivery Science and Technology
Volume88
Early online date31 Aug 2023
DOIs
Publication statusPublished - 1 Oct 2023

Bibliographical note

Funding Information:
LAMM and SN acknowledge an Erasmus + exchange studentship. VPT and LRT acknowledge funding via an EPSRC Research Fellowship for VPT [ EP/R01650×/1 ].

Publisher Copyright:
© 2023 The Authors

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