Controlling complexity and water penetration in functional de novo protein design

JLR Anderson, RL Koder, CC Moser, PL Dutton

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)

Abstract

Natural proteins are complex, and the engineering elements that support function and catalysis are obscure. Simplified synthetic protein scaffolds offer a means to avoid such complexity, learn the underlying principles behind the assembly of function and render the modular assembly of enzymatic function a tangible reality. A key feature of such protein design is the control and exclusion of water access to the protein core to provide the low-dielectric environment that enables enzymatic function. Recent successes in de novo protein design have illustrated how such control can be incorporated into the design process and have paved the way for the synthesis of nascent enzymatic activity in these systems.
Translated title of the contributionControlling complexity and water penetration in functional de novo protein design
Original languageEnglish
Pages (from-to)1106 - 1111
Number of pages8
JournalBiochemical Society Transactions
Volume36 (6)
DOIs
Publication statusPublished - Dec 2008

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