Projects per year
Abstract
Hebbian synaptic plasticity at hippocampal Schaffer collateral synapses is tightly regulated by postsynaptic small conductance (SK) channels that restrict NMDA receptor activity. SK channels are themselves modulated by G-protein-coupled signaling pathways, but it is not clear under what conditions these are activated to enable synaptic plasticity. Here, we show that muscarinic M1 receptor (M1R) and type 1 metabotropic glutamate receptor (mGluR1) signaling pathways, which are known to inhibit SK channels and thereby disinhibit NMDA receptors, converge to facilitate spine calcium transients during the induction of long-term potentiation (LTP) at hippocampal Schaffer collateral synapses onto CA1 pyramidal neurons of male rats. Furthermore, mGluR1 activation is required for LTP induced by reactivated place-cell firing patterns that occur in sharp-wave ripple events during rest or sleep. In contrast, M1R activation is required for LTP induced by place-cell firing patterns during exploration. Thus, we describe a common mechanism that enables synaptic plasticity during both encoding and consolidation of memories within hippocampal circuits.
Original language | English |
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Pages (from-to) | 9252-9262 |
Number of pages | 11 |
Journal | Journal of Neuroscience |
Volume | 38 |
Issue number | 43 |
Early online date | 24 Oct 2018 |
DOIs | |
Publication status | Published - 24 Oct 2018 |
Keywords
- hippocampus
- metabotropic glutamate receptors
- muscarinic receptors
- SK channels
- spike timing-dependent plasticity
- synaptic plasticity
Fingerprint
Dive into the research topics of 'Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus'. Together they form a unique fingerprint.Projects
- 2 Finished
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Neural adaptation to sensory stimuli by regulation of dendritic spikes and synaptic plasticity
Mellor, J. R. (Principal Investigator)
1/04/18 → 30/06/22
Project: Research
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Regulation of spine Ca2+ dynamics and spike timing-dependent synaptic plasticity by muscarinic acetylcholine receptors
Mellor, J. R. (Principal Investigator)
1/10/12 → 1/10/15
Project: Research
Profiles
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Dr Michael C Ashby
- School of Physiology, Pharmacology & Neuroscience - Senior Lecturer
- Bristol Neuroscience
Person: Academic , Member
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Professor Jack R Mellor
- School of Physiology, Pharmacology & Neuroscience - Professor in Neuroscience
- Bristol Neuroscience
Person: Academic , Member