Convergent syntheses of 3,6-dihydroxydec-4-enolides

Jonathan C Killen; Lorraine C Axford; Sarah E Newberry; Thomas J Simpson; Christine L Willis

doi:10.1021/ol3018566

Convergent syntheses of 3,6-dihydroxydec-4-enolides

Jonathan C Killen, Lorraine C Axford, Sarah E Newberry, Thomas J Simpson, Christine L Willis

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

16 Citations (Scopus)

Abstract

The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki-Hiyama-Kishi reaction in the key cyclization to generate the 6R stereocenter.

Original language	English
Pages (from-to)	4194-7
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	16
DOIs	https://doi.org/10.1021/ol3018566
Publication status	Published - 2012

Research Groups and Themes

Organic & Biological

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10.1021/ol3018566

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PROBING DRUG RECEPTOR BINDING SITES DRIVEN BY SOLID STATE NMR-AN INTERDISCIPLINARY APPROACH
Willis, C. L. (Principal Investigator)
1/11/06 → 1/05/12
Project: Research

Cite this

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title = "Convergent syntheses of 3,6-dihydroxydec-4-enolides",

abstract = "The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki-Hiyama-Kishi reaction in the key cyclization to generate the 6R stereocenter.",

author = "Killen, \{Jonathan C\} and Axford, \{Lorraine C\} and Newberry, \{Sarah E\} and Simpson, \{Thomas J\} and Willis, \{Christine L\}",

year = "2012",

doi = "10.1021/ol3018566",

language = "English",

volume = "14",

pages = "4194--7",

journal = "Organic Letters",

issn = "1523-7052",

publisher = "American Chemical Society",

number = "16",

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T1 - Convergent syntheses of 3,6-dihydroxydec-4-enolides

AU - Killen, Jonathan C

AU - Axford, Lorraine C

AU - Newberry, Sarah E

AU - Simpson, Thomas J

AU - Willis, Christine L

PY - 2012

Y1 - 2012

N2 - The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki-Hiyama-Kishi reaction in the key cyclization to generate the 6R stereocenter.

AB - The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki-Hiyama-Kishi reaction in the key cyclization to generate the 6R stereocenter.

U2 - 10.1021/ol3018566

DO - 10.1021/ol3018566

M3 - Article (Academic Journal)

C2 - 22849633

SN - 1523-7052

VL - 14

SP - 4194

EP - 4197

JO - Organic Letters

JF - Organic Letters

IS - 16

ER -

Convergent syntheses of 3,6-dihydroxydec-4-enolides

Abstract

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PROBING DRUG RECEPTOR BINDING SITES DRIVEN BY SOLID STATE NMR-AN INTERDISCIPLINARY APPROACH

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