Convergent synthesis of the tetrasaccharide repeating unit of the cell wall lipopolysaccharide of Escherichia coli O40

Abhijit Sau, Anup Kumar Misra*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)

Abstract

A tetrasaccharide repeating unit corresponding to the cell-wall lipopolysaccharide of E. coli O40 was synthesized by using a convergent block glycosylation strategy. A disaccharide donor was coupled to a disaccharide acceptor by a stereoselective glycosylation. A 2-aminoethyl linker was chosen as the anomeric protecting group at the reducing end of the tetrasaccharide. All glycosylation steps are significantly high yielding and stereoselective.

Original languageEnglish
Pages (from-to)2053-2059
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume8
DOIs
Publication statusPublished - 22 Nov 2012

Keywords

  • Escherichia coli
  • Glycosylation
  • Lipopolysaccharide
  • O-antigen; tetrasaccharide

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