Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells

Kankan Wang, Hai Fang, Dakai Xiao, Xuehua Zhu, Miaomiao He, Xiaoling Pan, Jiantao Shi, Hui Zhang, Xiaohong Jia, Yanzhi Du, Ji Zhang

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Abstract

Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death.
Original languageEnglish
Pages (from-to)e7538
JournalPLoS ONE
Volume4
Issue number10
DOIs
Publication statusPublished - 2009

Keywords

  • Proteasome Inhibitors
  • Apoptosis
  • Antineoplastic Agents
  • Endoplasmic Reticulum
  • HL-60 Cells
  • DNA-Binding Proteins
  • Humans
  • Protease Inhibitors
  • Gene Expression Regulation, Neoplastic
  • Oxidation-Reduction
  • Oxygen
  • Neoplasms
  • Transcription Factors
  • Oxidative Stress
  • Fenretinide
  • Signal Transduction
  • U937 Cells
  • NF-E2-Related Factor 2

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