Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells

Kankan Wang; Hai Fang; Dakai Xiao; Xuehua Zhu; Miaomiao He; Xiaoling Pan; Jiantao Shi; Hui Zhang; Xiaohong Jia; Yanzhi Du; Ji Zhang

doi:10.1371/journal.pone.0007538

Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells

Kankan Wang, Hai Fang, Dakai Xiao, Xuehua Zhu, Miaomiao He, Xiaoling Pan, Jiantao Shi, Hui Zhang, Xiaohong Jia, Yanzhi Du, Ji Zhang

Intelligent Systems Laboratory

Research output: Contribution to journal › Article (Academic Journal) › peer-review

33 Citations (Scopus)

Abstract

Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death.

Original language	English
Pages (from-to)	e7538
Journal	PLOS ONE
Volume	4
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0007538
Publication status	Published - 2009

Keywords

Proteasome Inhibitors
Apoptosis
Antineoplastic Agents
Endoplasmic Reticulum
HL-60 Cells
DNA-Binding Proteins
Humans
Protease Inhibitors
Gene Expression Regulation, Neoplastic
Oxidation-Reduction
Oxygen
Neoplasms
Transcription Factors
Oxidative Stress
Fenretinide
Signal Transduction
U937 Cells
NF-E2-Related Factor 2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0007538

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title = "Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells",

abstract = "Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death.",

keywords = "Proteasome Inhibitors, Apoptosis, Antineoplastic Agents, Endoplasmic Reticulum, HL-60 Cells, DNA-Binding Proteins, Humans, Protease Inhibitors, Gene Expression Regulation, Neoplastic, Oxidation-Reduction, Oxygen, Neoplasms, Transcription Factors, Oxidative Stress, Fenretinide, Signal Transduction, U937 Cells, NF-E2-Related Factor 2",

author = "Kankan Wang and Hai Fang and Dakai Xiao and Xuehua Zhu and Miaomiao He and Xiaoling Pan and Jiantao Shi and Hui Zhang and Xiaohong Jia and Yanzhi Du and Ji Zhang",

year = "2009",

doi = "10.1371/journal.pone.0007538",

language = "English",

volume = "4",

pages = "e7538",

journal = "PLOS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

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TY - JOUR

T1 - Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells

AU - Wang, Kankan

AU - Fang, Hai

AU - Xiao, Dakai

AU - Zhu, Xuehua

AU - He, Miaomiao

AU - Pan, Xiaoling

AU - Shi, Jiantao

AU - Zhang, Hui

AU - Jia, Xiaohong

AU - Du, Yanzhi

AU - Zhang, Ji

PY - 2009

Y1 - 2009

N2 - Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death.

AB - Pharmacological intervention of redox balance in cancer cells often results in oxidative stress-mediated apoptosis, attracting much attention for the development of a new generation of targeted therapy in cancer. However, little is known about mechanisms underlying the conversion from oxidative signaling to downstream activities leading cells to death.

KW - Proteasome Inhibitors

KW - Apoptosis

KW - Antineoplastic Agents

KW - Endoplasmic Reticulum

KW - HL-60 Cells

KW - DNA-Binding Proteins

KW - Humans

KW - Protease Inhibitors

KW - Gene Expression Regulation, Neoplastic

KW - Oxidation-Reduction

KW - Oxygen

KW - Neoplasms

KW - Transcription Factors

KW - Oxidative Stress

KW - Fenretinide

KW - Signal Transduction

KW - U937 Cells

KW - NF-E2-Related Factor 2

U2 - 10.1371/journal.pone.0007538

DO - 10.1371/journal.pone.0007538

M3 - Article (Academic Journal)

C2 - 19844581

SN - 1932-6203

VL - 4

SP - e7538

JO - PLOS ONE

JF - PLOS ONE

IS - 10

ER -

Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells

Abstract

Keywords

UN SDGs

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