Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.

Virginia C Gould; Aki Okazaki; Matthew B Avison

doi:10.1128/​AAC.01020-12

Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.

Virginia C Gould, Aki Okazaki, Matthew B Avison

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Abstract

A Stenotrophomonas maltophilia mutant has been identified that coordinately hyper-expresses three resistance nodulation division type efflux pump genes: smeZ, smeJ and smeK. SmeZ is responsible for elevating aminoglycoside MICs; SmeJK are jointly responsible for elevating tetracycline, minocycline and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate was identified from a sample of six with this same phenotype and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.

Original language	English
Pages (from-to)	655-657
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	1
Early online date	12 Nov 2012
DOIs	https://doi.org/10.1128/AAC.01020-12
Publication status	Published - 2013

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title = "Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.",

abstract = "A Stenotrophomonas maltophilia mutant has been identified that coordinately hyper-expresses three resistance nodulation division type efflux pump genes: smeZ, smeJ and smeK. SmeZ is responsible for elevating aminoglycoside MICs; SmeJK are jointly responsible for elevating tetracycline, minocycline and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate was identified from a sample of six with this same phenotype and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings. ",

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T1 - Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.

AU - Gould, Virginia C

AU - Okazaki, Aki

AU - Avison, Matthew B

PY - 2013

Y1 - 2013

N2 - A Stenotrophomonas maltophilia mutant has been identified that coordinately hyper-expresses three resistance nodulation division type efflux pump genes: smeZ, smeJ and smeK. SmeZ is responsible for elevating aminoglycoside MICs; SmeJK are jointly responsible for elevating tetracycline, minocycline and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate was identified from a sample of six with this same phenotype and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.

AB - A Stenotrophomonas maltophilia mutant has been identified that coordinately hyper-expresses three resistance nodulation division type efflux pump genes: smeZ, smeJ and smeK. SmeZ is responsible for elevating aminoglycoside MICs; SmeJK are jointly responsible for elevating tetracycline, minocycline and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate was identified from a sample of six with this same phenotype and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.

U2 - 10.1128/AAC.01020-12

DO - 10.1128/AAC.01020-12

M3 - Article (Academic Journal)

AN - SCOPUS:84872038448

SN - 0066-4804

VL - 57

SP - 655

EP - 657

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 1

ER -

Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.

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