Coordinate Hyper-Production of SmeZ and SmeJK Efflux Pumps Extends Drug Resistance in Stenotrophomonas maltophilia.

Research output: Contribution to journalArticle (Academic Journal)peer-review

38 Citations (Scopus)

Abstract

A Stenotrophomonas maltophilia mutant has been identified that coordinately hyper-expresses three resistance nodulation division type efflux pump genes: smeZ, smeJ and smeK. SmeZ is responsible for elevating aminoglycoside MICs; SmeJK are jointly responsible for elevating tetracycline, minocycline and ciprofloxacin MICs and conferring levofloxacin resistance. One clinical isolate was identified from a sample of six with this same phenotype and the isolate also coordinately hyper-expresses smeZ and smeJK, confirming the clinical relevance of our findings.
Original languageEnglish
Pages (from-to)655-657
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number1
Early online date12 Nov 2012
DOIs
Publication statusPublished - 2013

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