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Copper catalyzed Heck-like cyclizations of oxime esters are described. Mechanistic studies indicate a reaction pathway that proceeds via the generation and cyclization of an intermediate that possesses iminyl radical character. To the best of our knowledge, this work encompasses the first examples of Cu-catalyzed aza-Heck reactions that proceed via oxidative initiation at nitrogen to generate products containing a new alkene. This new protocol is also an effective alternative to Pd-based systems and highlights the value of replacing precious metal catalysts with cheaper and more sustainable variants. This journal is
|Number of pages||6|
|Early online date||9 Apr 2014|
|Publication status||Published - 1 Jun 2014|
- BCS and TECS CDTs
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- 2 Finished
3-month Core Capability for Chemistry Research
1/01/13 → 1/04/13
New Transition Metal Catalysed Methods for Alkyl C-N Bond Formation
Bower, J. F.
3/11/11 → 3/11/13