Copper catalyzed Heck-like cyclizations of oxime esters

Adele Faulkner, Nicholas J. Race, James S. Scott, John F. Bower*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

135 Citations (Scopus)
236 Downloads (Pure)


Copper catalyzed Heck-like cyclizations of oxime esters are described. Mechanistic studies indicate a reaction pathway that proceeds via the generation and cyclization of an intermediate that possesses iminyl radical character. To the best of our knowledge, this work encompasses the first examples of Cu-catalyzed aza-Heck reactions that proceed via oxidative initiation at nitrogen to generate products containing a new alkene. This new protocol is also an effective alternative to Pd-based systems and highlights the value of replacing precious metal catalysts with cheaper and more sustainable variants. This journal is

Original languageEnglish
Pages (from-to)2416-2421
Number of pages6
JournalChemical Science
Issue number6
Early online date9 Apr 2014
Publication statusPublished - 1 Jun 2014

Structured keywords

  • BCS and TECS CDTs


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