Corneal epitheliotrophic capacity of three different blood-derived preparations

Lei Liu, Dirk Hartwig, Susanne Harloff, Philip Herminghaus, Thilo Wedel, Karsten Kasper, Gerd Geerling

Research output: Contribution to journalArticle (Academic Journal)peer-review

78 Citations (Scopus)


Serum eye drops have been successfully used in the treatment of severe ocular surface disorders. Fresh frozen plasma (FFP) and platelet concentrates have not yet been tested for use as eye drops, although they are easily available as quality-controlled products from blood banks and are routinely used for transfusion. To test whether FFP or platelet-derived growth factor solutions could be used for ocular surface diseases, we compared the epitheliotrophic capacity of platelet releasate and FFP with that of serum in cell culture models.
Original languageEnglish
Pages (from-to)2438-44
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number6
Publication statusPublished - Jun 2006


  • Cell Movement
  • Animals
  • Corneal Diseases
  • Blood Proteins
  • Plasma
  • Wound Healing
  • Growth Substances
  • Humans
  • Cell Culture Techniques
  • Cell Differentiation
  • Rabbits
  • Cell Proliferation
  • Epithelium, Corneal
  • Blood Platelets
  • Serum
  • Middle Aged
  • Male
  • Microscopy, Electron, Scanning


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