Corneal epitheliotrophic capacity of three different blood-derived preparations

Lei Liu; Dirk Hartwig; Susanne Harloff; Philip Herminghaus; Thilo Wedel; Karsten Kasper; Gerd Geerling

doi:10.1167/iovs.05-0876

Corneal epitheliotrophic capacity of three different blood-derived preparations

Lei Liu, Dirk Hartwig, Susanne Harloff, Philip Herminghaus, Thilo Wedel, Karsten Kasper, Gerd Geerling

Research output: Contribution to journal › Article (Academic Journal) › peer-review

74 Citations (Scopus)

Abstract

Serum eye drops have been successfully used in the treatment of severe ocular surface disorders. Fresh frozen plasma (FFP) and platelet concentrates have not yet been tested for use as eye drops, although they are easily available as quality-controlled products from blood banks and are routinely used for transfusion. To test whether FFP or platelet-derived growth factor solutions could be used for ocular surface diseases, we compared the epitheliotrophic capacity of platelet releasate and FFP with that of serum in cell culture models.

Original language	English
Pages (from-to)	2438-44
Number of pages	7
Journal	Investigative Ophthalmology and Visual Science
Volume	47
Issue number	6
DOIs	https://doi.org/10.1167/iovs.05-0876
Publication status	Published - Jun 2006

Keywords

Cell Movement
Animals
Corneal Diseases
Blood Proteins
Plasma
Wound Healing
Growth Substances
Humans
Cell Culture Techniques
Cell Differentiation
Rabbits
Cell Proliferation
Epithelium, Corneal
Blood Platelets
Serum
Middle Aged
Male
Microscopy, Electron, Scanning

Access to Document

10.1167/iovs.05-0876

Handle.net

Persistent link

Cite this

@article{d4e4c06c2ef142ce89acc84507609791,

title = "Corneal epitheliotrophic capacity of three different blood-derived preparations",

abstract = "Serum eye drops have been successfully used in the treatment of severe ocular surface disorders. Fresh frozen plasma (FFP) and platelet concentrates have not yet been tested for use as eye drops, although they are easily available as quality-controlled products from blood banks and are routinely used for transfusion. To test whether FFP or platelet-derived growth factor solutions could be used for ocular surface diseases, we compared the epitheliotrophic capacity of platelet releasate and FFP with that of serum in cell culture models.",

keywords = "Cell Movement, Animals, Corneal Diseases, Blood Proteins, Plasma, Wound Healing, Growth Substances, Humans, Cell Culture Techniques, Cell Differentiation, Rabbits, Cell Proliferation, Epithelium, Corneal, Blood Platelets, Serum, Middle Aged, Male, Microscopy, Electron, Scanning",

author = "Lei Liu and Dirk Hartwig and Susanne Harloff and Philip Herminghaus and Thilo Wedel and Karsten Kasper and Gerd Geerling",

year = "2006",

month = jun,

doi = "10.1167/iovs.05-0876",

language = "English",

volume = "47",

pages = "2438--44",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "6",

}

TY - JOUR

T1 - Corneal epitheliotrophic capacity of three different blood-derived preparations

AU - Liu, Lei

AU - Hartwig, Dirk

AU - Harloff, Susanne

AU - Herminghaus, Philip

AU - Wedel, Thilo

AU - Kasper, Karsten

AU - Geerling, Gerd

PY - 2006/6

Y1 - 2006/6

N2 - Serum eye drops have been successfully used in the treatment of severe ocular surface disorders. Fresh frozen plasma (FFP) and platelet concentrates have not yet been tested for use as eye drops, although they are easily available as quality-controlled products from blood banks and are routinely used for transfusion. To test whether FFP or platelet-derived growth factor solutions could be used for ocular surface diseases, we compared the epitheliotrophic capacity of platelet releasate and FFP with that of serum in cell culture models.

AB - Serum eye drops have been successfully used in the treatment of severe ocular surface disorders. Fresh frozen plasma (FFP) and platelet concentrates have not yet been tested for use as eye drops, although they are easily available as quality-controlled products from blood banks and are routinely used for transfusion. To test whether FFP or platelet-derived growth factor solutions could be used for ocular surface diseases, we compared the epitheliotrophic capacity of platelet releasate and FFP with that of serum in cell culture models.

KW - Cell Movement

KW - Animals

KW - Corneal Diseases

KW - Blood Proteins

KW - Plasma

KW - Wound Healing

KW - Growth Substances

KW - Humans

KW - Cell Culture Techniques

KW - Cell Differentiation

KW - Rabbits

KW - Cell Proliferation

KW - Epithelium, Corneal

KW - Blood Platelets

KW - Serum

KW - Middle Aged

KW - Male

KW - Microscopy, Electron, Scanning

U2 - 10.1167/iovs.05-0876

DO - 10.1167/iovs.05-0876

M3 - Article (Academic Journal)

C2 - 16723454

SN - 0146-0404

VL - 47

SP - 2438

EP - 2444

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 6

ER -

Corneal epitheliotrophic capacity of three different blood-derived preparations

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this