Coronary artery restenosis and target lesion revascularisation in women by pregnancy history

Moa Pehrson; Andreas  Edsfeldt; Giovanna Sarno; Abigail Fraser; Janet W Rich-Edwards; Isabel Gonçalves; Mats Pihlsgård; Simon Timpka

doi:10.1136/openhrt-2022-002130

Coronary artery restenosis and target lesion revascularisation in women by pregnancy history

Moa Pehrson^*
, Andreas Edsfeldt
, Giovanna Sarno
, Abigail Fraser
, Janet W Rich-Edwards
, Isabel Gonçalves
, Mats Pihlsgård
, Simon Timpka

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Background
Women’s pregnancy history is associated with incident risk of coronary artery disease with some evidence also suggesting a relevance for prognosis following treatment.

Objectives
To study the associations between maternal history of preterm delivery, a history of small for gestational age infant, parity and age at first delivery with clinical restenosis after percutaneous coronary intervention (PCI).

Methods
In this prospective cohort study, we included 6027 women
Results
During 15 981 segment-years of follow-up, 343 (3.7%) events of clinical restenosis occurred. We found no strong evidence of associations between the studied aspects of pregnancy history and clinical restenosis following PCI. For example, the restenosis HR for a history of preterm delivery in the fully adjusted model was 1.09 (95% CI 0.77 to 1.55) and the TLR HR was 1.18 (95% CI 0.91 to 1.52).

Conclusion
Risk of restenosis following treatment with PCI did not differ by the studied aspects of pregnancy history, including preterm delivery, in young and middle-aged women. Larger studies are needed to obtain more precise estimates.

Original language	English
Article number	e002130
Number of pages	7
Journal	Open Heart
Volume	10
Issue number	1
DOIs	https://doi.org/10.1136/openhrt-2022-002130
Publication status	Published - 17 Mar 2023

Bibliographical note

Funding Information:
This work was supported by grants from the Swedish Research Council (2019-02082 to STi; to IG), The Swedish Heart-Lung Foundation (20180312 to STi; to IG), Public research support via the Faculty of Medicine at Lund University (ALF: YF-ALF, ALF project to STi; ALF project to Isabel Goncalves), The Swedish Society of Medicine (SLS-885331), The Jeansson Foundations, Stockholm, Sweden and Åke Wiberg Foundation, Stockholm, Sweden. This study was supported by the Swedish Research Council, Strategic Research Area Exodiab, Dnr 2009-1039 and Swedish Foundation for Strategic Research Dnr IRC15-0067.

Publisher Copyright:
© 2023 BMJ Publishing Group. All rights reserved.

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@article{26a061be2b16407bbe82aa07790c3e82,

title = "Coronary artery restenosis and target lesion revascularisation in women by pregnancy history",

abstract = "Background Women{\textquoteright}s pregnancy history is associated with incident risk of coronary artery disease with some evidence also suggesting a relevance for prognosis following treatment. Objectives To study the associations between maternal history of preterm delivery, a history of small for gestational age infant, parity and age at first delivery with clinical restenosis after percutaneous coronary intervention (PCI). Methods In this prospective cohort study, we included 6027 women Results During 15 981 segment-years of follow-up, 343 (3.7\%) events of clinical restenosis occurred. We found no strong evidence of associations between the studied aspects of pregnancy history and clinical restenosis following PCI. For example, the restenosis HR for a history of preterm delivery in the fully adjusted model was 1.09 (95\% CI 0.77 to 1.55) and the TLR HR was 1.18 (95\% CI 0.91 to 1.52). Conclusion Risk of restenosis following treatment with PCI did not differ by the studied aspects of pregnancy history, including preterm delivery, in young and middle-aged women. Larger studies are needed to obtain more precise estimates.",

author = "Moa Pehrson and Andreas Edsfeldt and Giovanna Sarno and Abigail Fraser and Rich-Edwards, \{Janet W\} and Isabel Gon{\c c}alves and Mats Pihlsg{\aa}rd and Simon Timpka",

note = "Funding Information: This work was supported by grants from the Swedish Research Council (2019-02082 to STi; to IG), The Swedish Heart-Lung Foundation (20180312 to STi; to IG), Public research support via the Faculty of Medicine at Lund University (ALF: YF-ALF, ALF project to STi; ALF project to Isabel Goncalves), The Swedish Society of Medicine (SLS-885331), The Jeansson Foundations, Stockholm, Sweden and {\AA}ke Wiberg Foundation, Stockholm, Sweden. This study was supported by the Swedish Research Council, Strategic Research Area Exodiab, Dnr 2009-1039 and Swedish Foundation for Strategic Research Dnr IRC15-0067. Publisher Copyright: {\textcopyright} 2023 BMJ Publishing Group. All rights reserved.",

year = "2023",

month = mar,

day = "17",

doi = "10.1136/openhrt-2022-002130",

language = "English",

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journal = "Open Heart",

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AU - Pehrson, Moa

AU - Edsfeldt, Andreas

AU - Sarno, Giovanna

AU - Fraser, Abigail

AU - Rich-Edwards, Janet W

AU - Gonçalves, Isabel

AU - Pihlsgård, Mats

AU - Timpka, Simon

N1 - Funding Information: This work was supported by grants from the Swedish Research Council (2019-02082 to STi; to IG), The Swedish Heart-Lung Foundation (20180312 to STi; to IG), Public research support via the Faculty of Medicine at Lund University (ALF: YF-ALF, ALF project to STi; ALF project to Isabel Goncalves), The Swedish Society of Medicine (SLS-885331), The Jeansson Foundations, Stockholm, Sweden and Åke Wiberg Foundation, Stockholm, Sweden. This study was supported by the Swedish Research Council, Strategic Research Area Exodiab, Dnr 2009-1039 and Swedish Foundation for Strategic Research Dnr IRC15-0067. Publisher Copyright: © 2023 BMJ Publishing Group. All rights reserved.

PY - 2023/3/17

Y1 - 2023/3/17

N2 - Background Women’s pregnancy history is associated with incident risk of coronary artery disease with some evidence also suggesting a relevance for prognosis following treatment. Objectives To study the associations between maternal history of preterm delivery, a history of small for gestational age infant, parity and age at first delivery with clinical restenosis after percutaneous coronary intervention (PCI). Methods In this prospective cohort study, we included 6027 women Results During 15 981 segment-years of follow-up, 343 (3.7%) events of clinical restenosis occurred. We found no strong evidence of associations between the studied aspects of pregnancy history and clinical restenosis following PCI. For example, the restenosis HR for a history of preterm delivery in the fully adjusted model was 1.09 (95% CI 0.77 to 1.55) and the TLR HR was 1.18 (95% CI 0.91 to 1.52). Conclusion Risk of restenosis following treatment with PCI did not differ by the studied aspects of pregnancy history, including preterm delivery, in young and middle-aged women. Larger studies are needed to obtain more precise estimates.

AB - Background Women’s pregnancy history is associated with incident risk of coronary artery disease with some evidence also suggesting a relevance for prognosis following treatment. Objectives To study the associations between maternal history of preterm delivery, a history of small for gestational age infant, parity and age at first delivery with clinical restenosis after percutaneous coronary intervention (PCI). Methods In this prospective cohort study, we included 6027 women Results During 15 981 segment-years of follow-up, 343 (3.7%) events of clinical restenosis occurred. We found no strong evidence of associations between the studied aspects of pregnancy history and clinical restenosis following PCI. For example, the restenosis HR for a history of preterm delivery in the fully adjusted model was 1.09 (95% CI 0.77 to 1.55) and the TLR HR was 1.18 (95% CI 0.91 to 1.52). Conclusion Risk of restenosis following treatment with PCI did not differ by the studied aspects of pregnancy history, including preterm delivery, in young and middle-aged women. Larger studies are needed to obtain more precise estimates.

U2 - 10.1136/openhrt-2022-002130

DO - 10.1136/openhrt-2022-002130

M3 - Article (Academic Journal)

C2 - 36931658

SN - 2053-3624

VL - 10

JO - Open Heart

JF - Open Heart

IS - 1

M1 - e002130

ER -

Coronary artery restenosis and target lesion revascularisation in women by pregnancy history

Abstract

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