Coronary heart disease

Adam S. Butterworth*, Julian P T Higgins, Nadeem Sarwar, John Danesh

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter in a book


Coronary heart disease (CHD) - which includes myocardial infarction, angina pectoris, and stenosis of the coronary arteries - is the leading cause of death worldwide, with over 7 million deaths per year. The tendency for CHD to cluster in families suggests that genetic variation, either directly or through modulation of known or as yet unidentified risk factors, importantly influences CHD risk. This chapter provides a critical and quantitative review of the current state of evidence regarding potential genetic susceptibility loci and CHD. It reviews published quantitative reviews of candidate gene polymorphisms and published GWAS addressing CHD.

Original languageEnglish
Title of host publicationHuman Genome Epidemiology: Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition
PublisherOxford University Press
ISBN (Print)9780199776023, 9780195398441
Publication statusPublished - 1 May 2010


  • Coronary heart disease
  • Genetic variants
  • Genetic variations
  • Genome-wide studies
  • Human disease
  • Risk factors


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