Corpse engulfment generates a molecular memory that primes the macrophage inflammatory response

Helen Weavers, Iwan R Evans, Paul Martin, Will Wood

Research output: Contribution to journalArticle (Academic Journal)peer-review

96 Citations (Scopus)
460 Downloads (Pure)

Abstract

Macrophages are multifunctional cells that perform diverse roles in health and disease. Emerging evidence has suggested that these innate immune cells might also be capable of developing immunological memory, a trait previously associated with the adaptive system alone. While recent studies have focused on the dramatic macrophage reprogramming that follows infection and protects against secondary microbial attack, can macrophages also develop memory in response to other cues? Here, we show that apoptotic corpse engulfment by Drosophila macrophages is an essential primer for their inflammatory response to tissue damage and infection in vivo. Priming is triggered via calcium-induced JNK signaling, which leads to upregulation of the damage receptor Draper, thus providing a molecular memory that allows the cell to rapidly respond to subsequent injury or infection. This remarkable plasticity and capacity for memory places macrophages as key therapeutic targets for treatment of inflammatory disorders.
Original languageEnglish
Pages (from-to)1658-1671
Number of pages14
JournalCell
Volume165
Issue number7
Early online date19 May 2016
DOIs
Publication statusPublished - 16 Jun 2016

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