Correlative Multimodal Imaging: Building a Community

Andreas Walter, Gerard J Kleywegt, Paul Verkade*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review


Few would have thought that when Porter and colleagues used light microscopy to target their cell of interest to be analyzed in the electron microscope in the 1940s, that Correlative Imaging would develop into the thriving field it is today.

Even though the first use of Correlative Light Electron Microscopy (CLEM) was established in the 1940s, it is only since the year 2000 that there has been a real surge in the application of CLEM technology. The power of CLEM is recognized in the scientific community as evidenced by the growing number of publications and dedicated sessions at scientific meetings. The field is also broadening, incorporating a multitude of other techniques including preclinical research and diagnostics, and slowly but surely the overarching field of Correlative Multimodality Imaging (CMI) is taking its place as an established technique and a research area in its own right.

In this chapter, we will look at the initiatives that are being developed within the scientific world to build a coherent CMI community, with a particular emphasis on the developments in Europe. To achieve this aim, the community will need to design mechanisms for the interdisciplinary exchange of knowledge and benefits, set up training schemes, and develop standards for CMI technology and its data.
Original languageEnglish
Number of pages14
JournalMethods in Cell Biology
Early online date19 Jan 2021
Publication statusE-pub ahead of print - 19 Jan 2021

Bibliographical note

provisional date of acceptance added, based on publication information.


  • Multimodality imaging across scales
  • Image archiving
  • Data deposition
  • CLEM
  • Training

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