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Cortical morphometry in anorexia nervosa: An out-of-sample replication study

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Cortical morphometry in anorexia nervosa : An out-of-sample replication study. / Leppanen, Jenni; Sedgewick, Felicity; Cardi, Valentina; Treasure, Janet; Tchanturia, Kate.

In: European Eating Disorders Review, 06.06.2019.

Research output: Contribution to journalArticle

Harvard

Leppanen, J, Sedgewick, F, Cardi, V, Treasure, J & Tchanturia, K 2019, 'Cortical morphometry in anorexia nervosa: An out-of-sample replication study', European Eating Disorders Review. https://doi.org/10.1002/erv.2686

APA

Leppanen, J., Sedgewick, F., Cardi, V., Treasure, J., & Tchanturia, K. (2019). Cortical morphometry in anorexia nervosa: An out-of-sample replication study. European Eating Disorders Review. https://doi.org/10.1002/erv.2686

Vancouver

Leppanen J, Sedgewick F, Cardi V, Treasure J, Tchanturia K. Cortical morphometry in anorexia nervosa: An out-of-sample replication study. European Eating Disorders Review. 2019 Jun 6. https://doi.org/10.1002/erv.2686

Author

Leppanen, Jenni ; Sedgewick, Felicity ; Cardi, Valentina ; Treasure, Janet ; Tchanturia, Kate. / Cortical morphometry in anorexia nervosa : An out-of-sample replication study. In: European Eating Disorders Review. 2019.

Bibtex

@article{8ab2c62b7b584762a217d849b2135fda,
title = "Cortical morphometry in anorexia nervosa: An out-of-sample replication study",
abstract = "BackgroundAcute anorexia nervosa (AN) is frequently accompanied by reduced global cortical volume. Investigations of local cortical alterations in AN have revealed widespread reduction in cortical thickness, gyrification, and curvature. The aim of the present study was to combine data from two previous studies to replicate previous findings.MethodologyMagnetic resonance imaging (MRI) images from 46 adult women with AN and 54 age‐matched healthy comparison (HC) women were analysed using FreeSurfer. Group differences in cortical volume and local cortical measures, including gyrification, curvature, thickness, and area, were examined controlling for dataset and age.ResultsThe AN group had reduced global cortical volume relative to the HC group. The AN group also had reduction in local cortical gyrification, small localised clusters of reduced cortical thickness, in the occipital and parietal cortices, and surface area in the frontal and temporal cortices. The AN group also had increased cortical thickness in the ACC relative to the HC participants.ConclusionsThe present findings replicate and validate previous findings of reduced global cortical volume and local gyrification in acute AN. The findings highlight the need for further investigation of local cortical folding, thickness, and surface area in AN to gain further insight into the biological underpinnings of AN.",
keywords = "anorexia nervosa, cortical folding, cortical surface area, cortical thickness, replication study",
author = "Jenni Leppanen and Felicity Sedgewick and Valentina Cardi and Janet Treasure and Kate Tchanturia",
year = "2019",
month = "6",
day = "6",
doi = "10.1002/erv.2686",
language = "English",
journal = "European Eating Disorders Review",
issn = "1067-1633",
publisher = "John Wiley & Sons, Inc",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Cortical morphometry in anorexia nervosa

T2 - An out-of-sample replication study

AU - Leppanen, Jenni

AU - Sedgewick, Felicity

AU - Cardi, Valentina

AU - Treasure, Janet

AU - Tchanturia, Kate

PY - 2019/6/6

Y1 - 2019/6/6

N2 - BackgroundAcute anorexia nervosa (AN) is frequently accompanied by reduced global cortical volume. Investigations of local cortical alterations in AN have revealed widespread reduction in cortical thickness, gyrification, and curvature. The aim of the present study was to combine data from two previous studies to replicate previous findings.MethodologyMagnetic resonance imaging (MRI) images from 46 adult women with AN and 54 age‐matched healthy comparison (HC) women were analysed using FreeSurfer. Group differences in cortical volume and local cortical measures, including gyrification, curvature, thickness, and area, were examined controlling for dataset and age.ResultsThe AN group had reduced global cortical volume relative to the HC group. The AN group also had reduction in local cortical gyrification, small localised clusters of reduced cortical thickness, in the occipital and parietal cortices, and surface area in the frontal and temporal cortices. The AN group also had increased cortical thickness in the ACC relative to the HC participants.ConclusionsThe present findings replicate and validate previous findings of reduced global cortical volume and local gyrification in acute AN. The findings highlight the need for further investigation of local cortical folding, thickness, and surface area in AN to gain further insight into the biological underpinnings of AN.

AB - BackgroundAcute anorexia nervosa (AN) is frequently accompanied by reduced global cortical volume. Investigations of local cortical alterations in AN have revealed widespread reduction in cortical thickness, gyrification, and curvature. The aim of the present study was to combine data from two previous studies to replicate previous findings.MethodologyMagnetic resonance imaging (MRI) images from 46 adult women with AN and 54 age‐matched healthy comparison (HC) women were analysed using FreeSurfer. Group differences in cortical volume and local cortical measures, including gyrification, curvature, thickness, and area, were examined controlling for dataset and age.ResultsThe AN group had reduced global cortical volume relative to the HC group. The AN group also had reduction in local cortical gyrification, small localised clusters of reduced cortical thickness, in the occipital and parietal cortices, and surface area in the frontal and temporal cortices. The AN group also had increased cortical thickness in the ACC relative to the HC participants.ConclusionsThe present findings replicate and validate previous findings of reduced global cortical volume and local gyrification in acute AN. The findings highlight the need for further investigation of local cortical folding, thickness, and surface area in AN to gain further insight into the biological underpinnings of AN.

KW - anorexia nervosa

KW - cortical folding

KW - cortical surface area

KW - cortical thickness

KW - replication study

U2 - 10.1002/erv.2686

DO - 10.1002/erv.2686

M3 - Article

JO - European Eating Disorders Review

JF - European Eating Disorders Review

SN - 1067-1633

ER -