Cortico-Striatal Connections Predict Control over Speed and Accuracy in Perceptual Decision Making

Forstmann Birte U., Anwander Alfred, Schäfer Andreas, Neumann Jane, Brown Scott, Wagenmakers Eric-Jan, R Bogacz, Turner Robert

Research output: Contribution to journalArticle (Academic Journal)peer-review

261 Citations (Scopus)

Abstract

When people make decisions they often face opposing demands for response speed and response accuracy, a process likely mediated by response thresholds. According to the striatal hypothesis, people decrease response thresholds by increasing activation from cortex to striatum, releasing the brain from inhibition. According to the STN hypothesis, people decrease response thresholds by decreasing activation from cortex to subthalamic nucleus (STN); a decrease in STN activity is likewise thought to release the brain from inhibition and result in responses that are fast but error-prone. To test these hypotheses – both of which may be true – we conducted two experiments on perceptual decision making in which we used cues to vary the demands for speed vs. accuracy. In both experiments, behavioral data and mathematical model analyses confirmed that instruction from the cue selectively affected the setting of response thresholds. In the first experiment, we used ultra high-resolution 7T structural magnetic resonance imaging (MRI) to locate the STN precisely. We then used 3T structural MRI and probabilistic tractography to quantify the connectivity between the relevant brain areas. The results showed that participants who flexibly change response thresholds (as quantified by the mathematical model) have strong structural connections between pre-supplementary motor area and striatum. This result was confirmed in an independent second experiment. In general, these findings show that individual differences in elementary cognitive tasks are partly driven by structural differences in brain connectivity. Specifically, these findings support a cortico-striatal control account of how the brain implements adaptive switches between cautious and risky behavior.
Translated title of the contributionCortico-Striatal Connections Predict Control over Speed and Accuracy in Perceptual Decision Making
Original languageEnglish
Article number15916-15920
Pages (from-to)15916 - 15920
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number36
DOIs
Publication statusPublished - Sep 2010

Bibliographical note

Other identifier: 2001234

Fingerprint

Dive into the research topics of 'Cortico-Striatal Connections Predict Control over Speed and Accuracy in Perceptual Decision Making'. Together they form a unique fingerprint.

Cite this