Corticosteroids and other anti-Inflammatory strategies in pediatric heart surgery: a national survey of practice

Daniel Fudulu, Alvin W L Schadenberg, Ben Gibbison, Ian A Jenkins, Stafford Lightman, Gianni Angelini, Serban Stoica

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
279 Downloads (Pure)

Abstract

BACKGROUND:
The role of steroids to mitigate the deleterious effects of pediatric cardiopulmonary bypass (CPB) remains a matter of debate; therefore, we aimed to assess preferences in administering corticosteroids (CSs) and the use of other anti-inflammatory strategies in pediatric cardiac surgery.

METHODS:
A 19-question survey was distributed to consultants in pediatric cardiac anesthesia from 12 centers across the United Kingdom and Ireland.

RESULTS:
Of the 37 respondents (37/60, 62%), 24 (65%) use CSs, while 13 (35%) do not use steroids at all. We found variability within 5 (41%) of the 12 centers. Seven consultants (7/24, 29%) administer CSs in every case, while 17 administer CSs in selected cases only (17/24, 71%). There was variability in the dose of steroid administration. Almost all consultants (23/24, 96%) administer a single dose at induction, and one administers a two-dose regimen (1/24, 4%). There was variability in CS indications. Most consultants (24/37, 66%) use modified ultrafiltration at the conclusion of CPB. Fifteen consultants (15/32, 47%) report the use of aprotinin, while only 3 use heparin-coated circuits (3/24, 9%).

CONCLUSIONS:
We found wide variability in practice in the administration of CSs for pediatric cardiac surgery, both within and between units. While most anesthetists administer CSs in at least some cases, there is no consensus on the type of steroid, the dose, and at which patient groups this should be directed. Modified ultrafiltration is still used by most of the centers. Almost half of consultants use aprotinin, while heparin-coated circuits are infrequently used.
Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalWorld Journal for Pediatric and Congenital Heart Surgery
Volume9
Issue number3
Early online date25 Apr 2018
DOIs
Publication statusPublished - May 2018

Structured keywords

  • Centre for Surgical Research

Keywords

  • Journal Article

Fingerprint Dive into the research topics of 'Corticosteroids and other anti-Inflammatory strategies in pediatric heart surgery: a national survey of practice'. Together they form a unique fingerprint.

  • Projects

    NIHR BRC Cardiovascular

    Angelini, G. D.

    1/04/1731/03/22

    Project: Research, Parent

    Cite this