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CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory

Research output: Contribution to journalArticle

Original languageEnglish
JournalLearning and Memory
DateAccepted/In press - 6 Nov 2019


The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterised. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6h or 24h retention delay, but no impairment was observed following delays of 5min or 3h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition.



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