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CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalLearning and Memory
Volume27
Issue number2
DOIs
DateAccepted/In press - 5 Nov 2019
DatePublished (current) - 1 Feb 2020

Abstract

The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition.

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  • Full-text PDF (author’s accepted manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Cold Spring Harbour Laboratory Press at http://learnmem.cshlp.org/content/27/2/45. Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 437 KB, PDF document

  • Full-text PDF (final published version)

    Rights statement: This is the final published version of the article (version of record). It first appeared online via Cold Harbor Laboratory Press at http://learnmem.cshlp.org/content/27/2/45. Please refer to any applicable terms of use of the publisher.

    Final published version, 1.48 MB, PDF document

    Embargo ends: 1/02/21

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    Licence: CC BY-NC

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