CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems

Yuiko Takebayashi, Emma S Taylor, Sam Whitwam, Matthew B Avison

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Mutants with enhanced growth in the presence of an antibiotic are more difficult to identify than mutants where the antibiotic's minimum inhibitory concentration increases, because they are not amenable to lethal selection in vitro. We report that activatory mutations in the CreC signal sensor enhance growth of Escherichia coli in the presence of cefoxitin, cefotaxime and meropenem without increasing their minimum inhibitory concentrations. Enhanced growth is dependent on over-production of the inner-membrane cre-regulon protein CreD.
Original languageEnglish
Article numbere00846-19
Number of pages16
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number11
Early online date26 Aug 2019
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • Fitness
  • Tolerance
  • Two-component system

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