Cross-Calibration of iDXA and pQCT Scanners at Rural and Urban Research Sites in The Gambia, West Africa

Mícheál Ó Breasail; Ramatoulie Janha; Ayse Zengin; Camille Pearse; Landing Jarjou; Ann Prentice; Kate A. Ward

doi:10.1007/s00223-023-01071-6

Cross-Calibration of iDXA and pQCT Scanners at Rural and Urban Research Sites in The Gambia, West Africa

Mícheál Ó Breasail^*, Ramatoulie Janha, Ayse Zengin, Camille Pearse, Landing Jarjou, Ann Prentice, Kate A. Ward

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1 Citation (Scopus)

51 Downloads (Pure)

Abstract

Between-scanner differences in measures of bone and body composition can obscure or exaggerate physiological differences in multi-site studies or the magnitude of changes in longitudinal studies. We conducted a cross-calibration study at two bone imaging centres in The Gambia, West Africa where DXA (dual-energy X-ray absorptiometry) and pQCT (peripheral Quantitative-Computed Tomography) are routinely used. Repeat scans were obtained from 64 Gambian adults (58% Male) aged Mean(SD) 30.9 (13.5) years with Mean(SD) body mass index (BMI) 21.7 (4.0) kg/m2, using DXA (GE Lunar iDXA, whole body [WB], total hip [TH], lumbar spine [LS]) and pQCT (Stratec XCT2000L/XCT2000, tibia 4%, 50% sites). Between-scanner differences were tested using paired t tests (p

Original language	English
Pages (from-to)	573–583
Number of pages	11
Journal	Calcified Tissue International
Volume	112
Issue number	5
DOIs	https://doi.org/10.1007/s00223-023-01071-6
Publication status	Published - 2 Mar 2023

Bibliographical note

Funding Information:
The authors wish to acknowledge the contribution of the participants who took part in this study. We thank the men and women of Kiang West and the Kombos, The Gambia, who patiently participated in the study. We acknowledge the enthusiastic work of the study team, especially the research and bone imaging staff, who tirelessly collected the data, and the drivers who transported the participants between facilities. The support of the data management team was greatly appreciated both during and after data collection. We are grateful to Michael Mendy and Mustapha Ceesay for their senior oversight of the bone imaging team. We also thank Dr. Sarah Dalzell for her help in planning the study. This research was jointly funded by the MRC (programme codes U105960371, U123261351, MCA760-5QX00) and the Department for International Development (DFID) under the MRC/DFID Concordat agreement. For the purposes of Open Access, the authors (KAW, AP) have applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.

Publisher Copyright:
© 2023, The Author(s).

Access to Document

10.1007/s00223-023-01071-6Licence: CC BY

Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Springer at https://doi.org/10.1007/s00223-023-01071-6 . Please refer to any applicable terms of use of the publisher.
Final published version, 1.61 MBLicence: CC BY

Handle.net

Persistent link

Cite this

@article{5d916e9acb7a43caad6de929d79a5181,

title = "Cross-Calibration of iDXA and pQCT Scanners at Rural and Urban Research Sites in The Gambia, West Africa",

abstract = "Between-scanner differences in measures of bone and body composition can obscure or exaggerate physiological differences in multi-site studies or the magnitude of changes in longitudinal studies. We conducted a cross-calibration study at two bone imaging centres in The Gambia, West Africa where DXA (dual-energy X-ray absorptiometry) and pQCT (peripheral Quantitative-Computed Tomography) are routinely used. Repeat scans were obtained from 64 Gambian adults (58\% Male) aged Mean(SD) 30.9 (13.5) years with Mean(SD) body mass index (BMI) 21.7 (4.0) kg/m2, using DXA (GE Lunar iDXA, whole body [WB], total hip [TH], lumbar spine [LS]) and pQCT (Stratec XCT2000L/XCT2000, tibia 4\%, 50\% sites). Between-scanner differences were tested using paired t tests (p ",

author = "\{{\'O} Breasail\}, M{\'i}che{\'a}l and Ramatoulie Janha and Ayse Zengin and Camille Pearse and Landing Jarjou and Ann Prentice and Ward, \{Kate A.\}",

note = "Funding Information: The authors wish to acknowledge the contribution of the participants who took part in this study. We thank the men and women of Kiang West and the Kombos, The Gambia, who patiently participated in the study. We acknowledge the enthusiastic work of the study team, especially the research and bone imaging staff, who tirelessly collected the data, and the drivers who transported the participants between facilities. The support of the data management team was greatly appreciated both during and after data collection. We are grateful to Michael Mendy and Mustapha Ceesay for their senior oversight of the bone imaging team. We also thank Dr. Sarah Dalzell for her help in planning the study. This research was jointly funded by the MRC (programme codes U105960371, U123261351, MCA760-5QX00) and the Department for International Development (DFID) under the MRC/DFID Concordat agreement. For the purposes of Open Access, the authors (KAW, AP) have applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = mar,

day = "2",

doi = "10.1007/s00223-023-01071-6",

language = "English",

volume = "112",

pages = "573–583",

journal = "Calcified Tissue International",

issn = "0171-967X",

publisher = "Springer",

number = "5",

}

TY - JOUR

T1 - Cross-Calibration of iDXA and pQCT Scanners at Rural and Urban Research Sites in The Gambia, West Africa

AU - Ó Breasail, Mícheál

AU - Janha, Ramatoulie

AU - Zengin, Ayse

AU - Pearse, Camille

AU - Jarjou, Landing

AU - Prentice, Ann

AU - Ward, Kate A.

N1 - Funding Information: The authors wish to acknowledge the contribution of the participants who took part in this study. We thank the men and women of Kiang West and the Kombos, The Gambia, who patiently participated in the study. We acknowledge the enthusiastic work of the study team, especially the research and bone imaging staff, who tirelessly collected the data, and the drivers who transported the participants between facilities. The support of the data management team was greatly appreciated both during and after data collection. We are grateful to Michael Mendy and Mustapha Ceesay for their senior oversight of the bone imaging team. We also thank Dr. Sarah Dalzell for her help in planning the study. This research was jointly funded by the MRC (programme codes U105960371, U123261351, MCA760-5QX00) and the Department for International Development (DFID) under the MRC/DFID Concordat agreement. For the purposes of Open Access, the authors (KAW, AP) have applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising. Publisher Copyright: © 2023, The Author(s).

PY - 2023/3/2

Y1 - 2023/3/2

N2 - Between-scanner differences in measures of bone and body composition can obscure or exaggerate physiological differences in multi-site studies or the magnitude of changes in longitudinal studies. We conducted a cross-calibration study at two bone imaging centres in The Gambia, West Africa where DXA (dual-energy X-ray absorptiometry) and pQCT (peripheral Quantitative-Computed Tomography) are routinely used. Repeat scans were obtained from 64 Gambian adults (58% Male) aged Mean(SD) 30.9 (13.5) years with Mean(SD) body mass index (BMI) 21.7 (4.0) kg/m2, using DXA (GE Lunar iDXA, whole body [WB], total hip [TH], lumbar spine [LS]) and pQCT (Stratec XCT2000L/XCT2000, tibia 4%, 50% sites). Between-scanner differences were tested using paired t tests (p

AB - Between-scanner differences in measures of bone and body composition can obscure or exaggerate physiological differences in multi-site studies or the magnitude of changes in longitudinal studies. We conducted a cross-calibration study at two bone imaging centres in The Gambia, West Africa where DXA (dual-energy X-ray absorptiometry) and pQCT (peripheral Quantitative-Computed Tomography) are routinely used. Repeat scans were obtained from 64 Gambian adults (58% Male) aged Mean(SD) 30.9 (13.5) years with Mean(SD) body mass index (BMI) 21.7 (4.0) kg/m2, using DXA (GE Lunar iDXA, whole body [WB], total hip [TH], lumbar spine [LS]) and pQCT (Stratec XCT2000L/XCT2000, tibia 4%, 50% sites). Between-scanner differences were tested using paired t tests (p

UR - https://doi.org/10.1007/s00223-023-01071-6

U2 - 10.1007/s00223-023-01071-6

DO - 10.1007/s00223-023-01071-6

M3 - Article (Academic Journal)

C2 - 36859609

SN - 0171-967X

VL - 112

SP - 573

EP - 583

JO - Calcified Tissue International

JF - Calcified Tissue International

IS - 5

ER -

Cross-Calibration of iDXA and pQCT Scanners at Rural and Urban Research Sites in The Gambia, West Africa

Abstract

Bibliographical note

Access to Document

Handle.net

Other files and links

Fingerprint

Cite this