Crystallisation From Volatile Deep Eutectic Solvents

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.
Original languageEnglish
JournalCrystal Growth and Design
Early online date27 Apr 2020
DOIs
Publication statusE-pub ahead of print - 27 Apr 2020

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