Crystallisation From Volatile Deep Eutectic Solvents

Jason Potticary; Charlie Hall; Victoria Hamilton; James F. McCabe; Simon R Hall

doi:10.1021/acs.cgd.0c00399

Crystallisation From Volatile Deep Eutectic Solvents

Jason Potticary, Charlie Hall, Victoria Hamilton, James F. McCabe, Simon R Hall

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.

Original language	English
Journal	Crystal Growth and Design
Early online date	27 Apr 2020
DOIs	https://doi.org/10.1021/acs.cgd.0c00399
Publication status	E-pub ahead of print - 27 Apr 2020

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10.1021/acs.cgd.0c00399

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AU - Potticary, Jason

AU - Hall, Charlie

AU - Hamilton, Victoria

AU - McCabe, James F.

AU - Hall, Simon R

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N2 - A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.

AB - A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.

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DO - 10.1021/acs.cgd.0c00399

M3 - Article (Academic Journal)

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