TY - JOUR
T1 - Crystallisation From Volatile Deep Eutectic Solvents
AU - Potticary, Jason
AU - Hall, Charlie
AU - Hamilton, Victoria
AU - McCabe, James F.
AU - Hall, Simon R
PY - 2020/4/27
Y1 - 2020/4/27
N2 - A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.
AB - A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.
U2 - 10.1021/acs.cgd.0c00399
DO - 10.1021/acs.cgd.0c00399
M3 - Article (Academic Journal)
SN - 1528-7483
JO - Crystal Growth and Design
JF - Crystal Growth and Design
ER -