Abstract
Crystallographic analyses of the VIM-5 metallo-β-lactamase (MBL) with isoquinoline inhibitors reveal non zinc ion binding modes. Comparison with other MBL-inhibitor structures directed addition of a zinc-binding thiol enabling identification of potent B1 MBL inhibitors. The inhibitors potentiate meropenem activity against clinical isolates harboring MBLs.
Original language | English |
---|---|
Pages (from-to) | 5806-5809 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 53 |
Issue number | 43 |
DOIs | |
Publication status | Published - 30 May 2017 |
Keywords
- Journal Article