Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility

Shoupeng  Cao; Hanglong  Wu; Imke A. B Pijpers; Jingxin  Shao; Loai K. E. A Abdelmohsen; David S Williams; Jan C. M. van Hest

doi:10.1021/acsnano.1c07343

Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility

Shoupeng Cao, Hanglong Wu, Imke A. B Pijpers, Jingxin Shao ^*, Loai K. E. A Abdelmohsen^*, David S Williams^*, Jan C. M. van Hest^*

^*Corresponding author for this work

School of Cellular and Molecular Medicine

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Polymersomes that incorporate aggregation-induced emission (AIE) moieties are attractive inherently fluorescent nanoparticles with biomedical application potential for cell/tissue imaging and tracking, as well as phototherapeutics. An intriguing feature that has not been explored yet is their ability to adopt a range of asymmetric morphologies. Structural asymmetry allows nanoparticles to be exploited as active (motile) systems. Here, we present the design and preparation of AIE fluorophore integrated (AIEgenic) cucurbit-shaped polymersome nanomotors with enzyme-powered motility. The cucurbit scaffold was constructed via morphology engineering of biodegradable fluorescent AIE-polymersomes, followed by functionalization with enzymatic machinery via a layer-by-layer (LBL) self-assembly process. Because of the enzyme-mediated decomposition of chemical fuel on the cucurbit-like nanomotor surface, enhanced directed motion was attained, when compared with the spherical counterparts. These cucurbit-shaped biodegradable AIE-nanomotors provide a promising platform for the development of active delivery systems with potential for biomedical applications.

Original language	English
Number of pages	9
Journal	ACS Nano
Volume	(2021)
Early online date	20 Oct 2021
DOIs	https://doi.org/10.1021/acsnano.1c07343
Publication status	E-pub ahead of print - 20 Oct 2021

Bibliographical note

Funding Information:
The authors would like to acknowledge the ERC Advanced Grant Artisym 694120, the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035), the NWO-NSFC Advanced Materials (project 792.001.015), and the European Union’s Horizon 2020 research and innovation program Marie Sklodowska-Curie Innovative Training Networks Nanomed, (No. 676137) for funding. We thank the Ser Cymru II program for support of DSW; this project received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 663830. We also thank A. F. Mason for help with Cryo-TEM measurements.

Publisher Copyright:
© 2021 The Authors. Published by American Chemical Society.

Keywords

polymersomes
nanomotors
aggregation-induced emission
morphology engineering
LBL assembly

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title = "Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility",

abstract = "Polymersomes that incorporate aggregation-induced emission (AIE) moieties are attractive inherently fluorescent nanoparticles with biomedical application potential for cell/tissue imaging and tracking, as well as phototherapeutics. An intriguing feature that has not been explored yet is their ability to adopt a range of asymmetric morphologies. Structural asymmetry allows nanoparticles to be exploited as active (motile) systems. Here, we present the design and preparation of AIE fluorophore integrated (AIEgenic) cucurbit-shaped polymersome nanomotors with enzyme-powered motility. The cucurbit scaffold was constructed via morphology engineering of biodegradable fluorescent AIE-polymersomes, followed by functionalization with enzymatic machinery via a layer-by-layer (LBL) self-assembly process. Because of the enzyme-mediated decomposition of chemical fuel on the cucurbit-like nanomotor surface, enhanced directed motion was attained, when compared with the spherical counterparts. These cucurbit-shaped biodegradable AIE-nanomotors provide a promising platform for the development of active delivery systems with potential for biomedical applications.",

keywords = "polymersomes, nanomotors, aggregation-induced emission, morphology engineering, LBL assembly",

author = "Shoupeng Cao and Hanglong Wu and Pijpers, {Imke A. B} and Jingxin Shao and Abdelmohsen, {Loai K. E. A} and Williams, {David S} and {van Hest}, {Jan C. M.}",

note = "Funding Information: The authors would like to acknowledge the ERC Advanced Grant Artisym 694120, the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035), the NWO-NSFC Advanced Materials (project 792.001.015), and the European Union{\textquoteright}s Horizon 2020 research and innovation program Marie Sklodowska-Curie Innovative Training Networks Nanomed, (No. 676137) for funding. We thank the Ser Cymru II program for support of DSW; this project received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under the Marie Sk{\l}odowska-Curie grant agreement No. 663830. We also thank A. F. Mason for help with Cryo-TEM measurements. Publisher Copyright: {\textcopyright} 2021 The Authors. Published by American Chemical Society.",

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AU - Shao , Jingxin

AU - Abdelmohsen, Loai K. E. A

AU - Williams, David S

AU - van Hest, Jan C. M.

N1 - Funding Information: The authors would like to acknowledge the ERC Advanced Grant Artisym 694120, the Dutch Ministry of Education, Culture and Science (Gravitation program 024.001.035), the NWO-NSFC Advanced Materials (project 792.001.015), and the European Union’s Horizon 2020 research and innovation program Marie Sklodowska-Curie Innovative Training Networks Nanomed, (No. 676137) for funding. We thank the Ser Cymru II program for support of DSW; this project received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 663830. We also thank A. F. Mason for help with Cryo-TEM measurements. Publisher Copyright: © 2021 The Authors. Published by American Chemical Society.

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N2 - Polymersomes that incorporate aggregation-induced emission (AIE) moieties are attractive inherently fluorescent nanoparticles with biomedical application potential for cell/tissue imaging and tracking, as well as phototherapeutics. An intriguing feature that has not been explored yet is their ability to adopt a range of asymmetric morphologies. Structural asymmetry allows nanoparticles to be exploited as active (motile) systems. Here, we present the design and preparation of AIE fluorophore integrated (AIEgenic) cucurbit-shaped polymersome nanomotors with enzyme-powered motility. The cucurbit scaffold was constructed via morphology engineering of biodegradable fluorescent AIE-polymersomes, followed by functionalization with enzymatic machinery via a layer-by-layer (LBL) self-assembly process. Because of the enzyme-mediated decomposition of chemical fuel on the cucurbit-like nanomotor surface, enhanced directed motion was attained, when compared with the spherical counterparts. These cucurbit-shaped biodegradable AIE-nanomotors provide a promising platform for the development of active delivery systems with potential for biomedical applications.

AB - Polymersomes that incorporate aggregation-induced emission (AIE) moieties are attractive inherently fluorescent nanoparticles with biomedical application potential for cell/tissue imaging and tracking, as well as phototherapeutics. An intriguing feature that has not been explored yet is their ability to adopt a range of asymmetric morphologies. Structural asymmetry allows nanoparticles to be exploited as active (motile) systems. Here, we present the design and preparation of AIE fluorophore integrated (AIEgenic) cucurbit-shaped polymersome nanomotors with enzyme-powered motility. The cucurbit scaffold was constructed via morphology engineering of biodegradable fluorescent AIE-polymersomes, followed by functionalization with enzymatic machinery via a layer-by-layer (LBL) self-assembly process. Because of the enzyme-mediated decomposition of chemical fuel on the cucurbit-like nanomotor surface, enhanced directed motion was attained, when compared with the spherical counterparts. These cucurbit-shaped biodegradable AIE-nanomotors provide a promising platform for the development of active delivery systems with potential for biomedical applications.

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KW - LBL assembly

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DO - 10.1021/acsnano.1c07343

M3 - Article (Academic Journal)

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JF - ACS Nano

SN - 1936-0851

ER -

Cucurbit-Like Polymersomes with Aggregation-Induced Emission Properties Show Enzyme-Mediated Motility

Abstract

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Keywords

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