Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies

Amy Campbell; Marcus R Munafò; Hannah M Sallis; Rebecca M Pearson; Daniel Smith

doi:10.1017/S0140525X21001795

Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies

Amy Campbell, Marcus R Munafò, Hannah M Sallis, Rebecca M Pearson, Daniel Smith

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Abstract

Cultural effects can influence the results of causal genetic analyses, such as Mendelian randomisation, but the potential influences of culture on genotype-phenotype associations are not currently well understood. Different genetic variants could be associated with different phenotypes in different populations, or culture could confound or influence the direction of the association between genotypes and phenotypes in different populations.

Original language	English
Article number	e158
Journal	The Behavioral and brain sciences
Volume	45
DOIs	https://doi.org/10.1017/S0140525X21001795
Publication status	Published - 13 Sep 2022

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© The Author(s), 2022. Published by Cambridge University Press.

Keywords

Mendelian Randomization Analysis/methods

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10.1017/S0140525X21001795

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abstract = "Cultural effects can influence the results of causal genetic analyses, such as Mendelian randomisation, but the potential influences of culture on genotype-phenotype associations are not currently well understood. Different genetic variants could be associated with different phenotypes in different populations, or culture could confound or influence the direction of the association between genotypes and phenotypes in different populations.",

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AU - Munafò, Marcus R

AU - Sallis, Hannah M

AU - Pearson, Rebecca M

AU - Smith, Daniel

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AB - Cultural effects can influence the results of causal genetic analyses, such as Mendelian randomisation, but the potential influences of culture on genotype-phenotype associations are not currently well understood. Different genetic variants could be associated with different phenotypes in different populations, or culture could confound or influence the direction of the association between genotypes and phenotypes in different populations.

KW - Mendelian Randomization Analysis/methods

U2 - 10.1017/S0140525X21001795

DO - 10.1017/S0140525X21001795

M3 - Article (Academic Journal)

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JO - Behavioral and Brain Sciences

JF - Behavioral and Brain Sciences

SN - 0140-525X

M1 - e158

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Culture and causal inference: The impact of cultural differences on the generalisability of findings from Mendelian randomisation studies

Abstract

Bibliographical note

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