Current concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation

RWJ Lee, AD Dick

Research output: Contribution to journalArticle (Academic Journal)peer-review

40 Citations (Scopus)

Abstract

The blockbuster drug paradigm is under increasing scrutiny across the biopharmaceutical industry. Intraocular inflammation poses particular challenges to this, given the heterogeneity of conditions in the uveitis spectrum, and the increasing acknowledgement of individual patient and disease variance in underlying immune responses. This need has triggered a drive towards personalised and stratified medicine, supported and enabled as a result of continued development of both experimental models and molecular biological techniques and improved clinical classification. As such we have the ability now to systematically appraise at a genomic, transcriptomic, and proteomic level individual immunophenotype, and the promise that in the eye this can be augmented by in vivo immune imaging to identify individual immunopathology. With such advances all running in parallel, we are entering an era of experimental medicine that will facilitate early diagnosis, generate biomarkers for accurate prognostication, and enable the development of individualised and targeted therapies, which can progress rapidly into clinical practice.Eye advance online publication, 30 September 2011; doi:10.1038/eye.2011.255.
Translated title of the contributionCurrent concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation
Original languageEnglish
Pages (from-to)17 - 28
Number of pages12
JournalEye
Volume26(1)
DOIs
Publication statusPublished - Jan 2012

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