Current perspectives on vitamin D, immune system, and chronic diseases

Maria C Borges, Lígia A Martini, Marcelo M Rogero

Research output: Contribution to journalArticle (Academic Journal)peer-review

103 Citations (Scopus)


Accumulating data support that vitamin D possesses several biological and molecular actions apart from its role in calcium homeostasis. Immune cells express vitamin D receptor and are capable of metabolizing vitamin D. Within this context, experimental studies show that vitamin D modulates immune and inflammatory responses. Epidemiologic evidence linking poor vitamin D status to autoimmune diseases, type 2 diabetes, and cardiovascular disease suggests that insufficient vitamin D may be involved in the etiology of such disorders. Given the impact of immune and inflammatory abnormalities in the development of chronic diseases, including autoimmune disorders, it is possible that vitamin D might reduce chronic disease risk by modulating the immune system.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
Issue number4
Publication statusPublished - Apr 2011


  • Animals
  • Autoimmune Diseases
  • Cardiovascular Diseases
  • Diabetes Mellitus, Type 2
  • Humans
  • Immunologic Factors
  • Inflammation
  • Receptors, Calcitriol
  • Vitamin D
  • Vitamin D Deficiency


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