Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP

Eunsil Cho, Dong-Hyun Kim, Young-Na Hur, Daniel J Whitcomb, Philip Regan, Jung-Hwa Hong, Hanna Kim, Young Ho Suh, Kwangwook Cho, Mikyoung Park

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)
316 Downloads (Pure)


Cyclin Y (CCNY) is a member of the cyclin protein family, known to regulate cell division in proliferating cells. Interestingly, CCNY is expressed in neurons that do not undergo cell division. Here, we report that CCNY negatively regulates long-term potentiation (LTP) of synaptic strength through inhibition of AMPA receptor trafficking. CCNY is enriched in postsynaptic fractions from rat forebrain and is localized adjacent to postsynaptic sites in dendritic spines in rat hippocampal neurons. Using live-cell imaging of a pH-sensitive AMPA receptor, we found that during LTP-inducing stimulation, CCNY inhibits AMPA receptor exocytosis in dendritic spines. Furthermore, CCNY abolishes LTP in hippocampal slices. Taken together, our findings demonstrate that CCNY inhibits plasticity-induced AMPA receptor delivery to synapses and thereby blocks LTP, identifying a novel function for CCNY in post-mitotic cells.

Original languageEnglish
Article number12624
Number of pages14
JournalScientific Reports
Publication statusPublished - 29 Jul 2015


  • Cellular neuroscience
  • Long-term potentiation
  • Molecular neuroscience


Dive into the research topics of 'Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP'. Together they form a unique fingerprint.

Cite this