Abstract
Based on quantitative cyto- and receptor architectonic analyses, we identified 35 prefrontal areas, including novel subdivisions of Walker’s areas 10, 9, 8B, and 46. Statistical analysis of receptor densities revealed regional differences in lateral and ventrolateral prefrontal cortex. Indeed, structural and functional organization of subdivisions encompassing areas 46 and 12 demonstrated significant differences in the interareal levels of α2 receptors. Furthermore, multivariate analysis included receptor fingerprints of previously identified 16 motor areas in the same macaque brains and revealed 5 clusters encompassing frontal lobe areas. We used the MRI datasets from the non-human primate data sharing consortium PRIME-DE to perform functional connectivity analyses using the resulting frontal maps as seed regions. In general, rostrally located frontal areas were characterized by bigger fingerprints, that is, higher receptor densities, and stronger regional interconnections. Whereas more caudal areas had smaller fingerprints, but showed a widespread connectivity pattern with distant cortical regions. Taken together, this study provides a comprehensive insight into the molecular structure underlying the functional organization of the cortex and, thus, reconcile the discrepancies between the structural and functional hierarchical organization of the primate frontal lobe. Finally, our data are publicly available via the EBRAINS and BALSA repositories for the entire scientific community.
| Original language | English |
|---|---|
| Article number | e82850 |
| Journal | eLife |
| Early online date | 14 Aug 2023 |
| DOIs | |
| Publication status | E-pub ahead of print - 14 Aug 2023 |
Bibliographical note
Funding Information:Open Access publication costs are funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 491111487. Katrin Amunts and Nicola Palomero-Gallagher: founder: European Union’s Horizon 2020; grant reference number: 945539 (Human Brain Project SGA3); founder: Helmholtz Association’s Initiative and Networking Fund; grant reference number: InterLabs-0015. Nicola Palomero-Gallagher: founder: Federal Ministry of Education and Research (BMBF); grant reference number: 01GQ1902. Xiao-Jing Wang: founder: National Institute of Health (NIH); grant reference number: R01MH122024-02. The founders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be acknowledged as a potential conflict of interest.
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