Cytokines in psychosis: from mechanism towards treatment and prediction

Éimear M Foley; Golam M Khandaker

doi:10.1016/S2215-0366(23)00056-1

Cytokines in psychosis: from mechanism towards treatment and prediction

Éimear M Foley, Golam M Khandaker

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33 Downloads (Pure)

Abstract

Identifying risk factors that distinguish disease onset from chronicity is crucial for understanding potential causal mechanisms and to devise effective strategies for treatment, prevention, and prediction. Studies of peripheral blood concentrations of inflammatory markers, such as cytokines (eg, interleukin [IL]-6) and acute-phase proteins (eg, C-reactive protein), have provided some of the most consistent evidence implicating low-grade systemic inflammation in schizophrenia and related psychotic disorders. 1 These studies have hitherto been subject to several systematic reviews and meta-analyses. 2 , 3 In this issue of The Lancet Psychiatry, Sean Halstead and colleagues 4 add to this evidence base through a systematic review and meta-analysis of blood inflammatory marker alterations in patients with acute and chronic schizophrenia-spectrum disorder.

Original language	English
Pages (from-to)	237-239
Number of pages	3
Journal	Lancet Psychiatry
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/S2215-0366(23)00056-1
Publication status	Published - 27 Feb 2023

Keywords

Humans
Cytokines
Psychotic Disorders/therapy
Psychiatric Status Rating Scales

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10.1016/S2215-0366(23)00056-1

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This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://doi.org/10.1016/S2215-0366(23)00056-1.  Please refer to any applicable terms of use of the publisher.
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title = "Cytokines in psychosis: from mechanism towards treatment and prediction",

abstract = "Identifying risk factors that distinguish disease onset from chronicity is crucial for understanding potential causal mechanisms and to devise effective strategies for treatment, prevention, and prediction. Studies of peripheral blood concentrations of inflammatory markers, such as cytokines (eg, interleukin [IL]-6) and acute-phase proteins (eg, C-reactive protein), have provided some of the most consistent evidence implicating low-grade systemic inflammation in schizophrenia and related psychotic disorders. 1 These studies have hitherto been subject to several systematic reviews and meta-analyses. 2 , 3 In this issue of The Lancet Psychiatry, Sean Halstead and colleagues 4 add to this evidence base through a systematic review and meta-analysis of blood inflammatory marker alterations in patients with acute and chronic schizophrenia-spectrum disorder.",

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T1 - Cytokines in psychosis

T2 - from mechanism towards treatment and prediction

AU - Foley, Éimear M

AU - Khandaker, Golam M

PY - 2023/2/27

Y1 - 2023/2/27

N2 - Identifying risk factors that distinguish disease onset from chronicity is crucial for understanding potential causal mechanisms and to devise effective strategies for treatment, prevention, and prediction. Studies of peripheral blood concentrations of inflammatory markers, such as cytokines (eg, interleukin [IL]-6) and acute-phase proteins (eg, C-reactive protein), have provided some of the most consistent evidence implicating low-grade systemic inflammation in schizophrenia and related psychotic disorders. 1 These studies have hitherto been subject to several systematic reviews and meta-analyses. 2 , 3 In this issue of The Lancet Psychiatry, Sean Halstead and colleagues 4 add to this evidence base through a systematic review and meta-analysis of blood inflammatory marker alterations in patients with acute and chronic schizophrenia-spectrum disorder.

AB - Identifying risk factors that distinguish disease onset from chronicity is crucial for understanding potential causal mechanisms and to devise effective strategies for treatment, prevention, and prediction. Studies of peripheral blood concentrations of inflammatory markers, such as cytokines (eg, interleukin [IL]-6) and acute-phase proteins (eg, C-reactive protein), have provided some of the most consistent evidence implicating low-grade systemic inflammation in schizophrenia and related psychotic disorders. 1 These studies have hitherto been subject to several systematic reviews and meta-analyses. 2 , 3 In this issue of The Lancet Psychiatry, Sean Halstead and colleagues 4 add to this evidence base through a systematic review and meta-analysis of blood inflammatory marker alterations in patients with acute and chronic schizophrenia-spectrum disorder.

KW - Humans

KW - Cytokines

KW - Psychotic Disorders/therapy

KW - Psychiatric Status Rating Scales

U2 - 10.1016/S2215-0366(23)00056-1

DO - 10.1016/S2215-0366(23)00056-1

M3 - Article (Academic Journal)

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SN - 2215-0366

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EP - 239

JO - Lancet Psychiatry

JF - Lancet Psychiatry

IS - 4

ER -

Cytokines in psychosis: from mechanism towards treatment and prediction

Abstract

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