Cytoplasmic dynein-2 at a glance

Laura Vuolo, Nicola L Stevenson, Aakash G. Mukhopadhyay, Anthony J. Roberts, David Stephens

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Cytoplasmic dynein-2 is a motor protein complex that drives the movement of cargoes along microtubules within cilia, facilitating the assembly of these organelles on the surface of nearly all mammalian cells. Dynein-2 is crucial for ciliary function, as evidenced by deleterious mutations in patients with skeletal abnormalities. Long-standing questions include how the dynein-2 complex is assembled, regulated, and switched between active and inactive states. A combination of model organisms, in vitro cell biology, live-cell imaging, structural biology and biochemistry has advanced our understanding of the dynein-2 motor. In this Cell Science at a Glance article and the accompanying poster, we discuss the current understanding of dynein-2 and its roles in ciliary assembly and function.
Original languageEnglish
JournalJournal of Cell Science
Early online date30 Mar 2020
DOIs
Publication statusE-pub ahead of print - 30 Mar 2020

Keywords

  • dynein-2
  • cilia
  • intraflagellar transport
  • microtubule motors

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