Daidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States

C Atkinson, KM Newton, EJA Bowles, CD Lehman, FZ Stanczyk, KC Westerlind, L Li, JW Lampe

Research output: Contribution to journalArticle (Academic Journal)peer-review

15 Citations (Scopus)

Abstract

BACKGROUND: Mammographic breast density is an established marker of breast cancer risk, and is hormonally sensitive. Studies suggest that production of the daidzein metabolites equol and O-Desmethylangolensin (ODMA) may be associated with hormones and hormonally mediated factors, but few studies have assessed relationships between the capacity to produce these metabolites and breast density. OBJECTIVE: To evaluate the relationship between equol- and ODMA-producer phenotypes and breast density in premenopausal women in the United States. DESIGN: Two hundred and three women attended a clinic visit and 200 provided a urine sample following a 3 day soy challenge. Samples were analyzed for isoflavones by GC-MS to determine daidzein-metabolizing phenotypes. Percent density on recent (87.5 ng/ml urine), respectively. In unadjusted and adjusted analyses, there were no differences in breast density between producers and non-producers of either equol or ODMA (P > 0.05). CONCLUSION: In this population of low-soy consuming premenopausal women, there were no associations between daidzein-metabolizing phenotypes and breast density, suggesting that these phenotypes per se do not influence premenopausal breast density.
Translated title of the contributionDaidzein-metabolizing phenotypes in relation to mammographic breast density among premenopausal women in the United States
Original languageEnglish
Pages (from-to)587 - 594
JournalBreast Cancer Research and Treatment
Volume116(3)
DOIs
Publication statusPublished - Aug 2009

Bibliographical note

Publisher: Kluwer Academic

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