DCDC2, KIAA0319 and CMIP are associated with reading-related traits

Scerri Tom S., Morris Andrew P., Buckingham Lyn-Louise, Newbury Dianne F., LL Miller, Monaco Anthony P., J Golding, Bishop Dorothy, Paracchini Silvia

Research output: Contribution to journalArticle (Academic Journal)

107 Citations (Scopus)

Abstract

Background
Several susceptibility genes have been proposed for dyslexia (reading disability; RD) and specific language impairment (SLI). RD and SLI show comorbidity, but it is unclear whether a common genetic component is shared.

Methods
We have investigated whether candidate genes for RD and SLI affect specific cognitive traits or have broad effect on cognition. We have analyzed common risk variants within RD (MRPL19/C2ORF3, KIAA0319, and DCDC2) and language impairment (CMIP and ATP2C2) candidate loci in the Avon Longitudinal Study of Parents and Children cohort (n = 3725), representing children born in southwest England in the early 1990s.

Results
We detected associations between reading skills and KIAA0319, DCDC2, and CMIP. We show that DCDC2 is specifically associated with RD, whereas variants in CMIP and KIAA0319 are associated with reading skills across the ability range. The strongest associations were restricted to single-word reading and spelling measures, suggesting that these genes do not extend their effect to other reading and language-related skills. Inclusion of individuals with comorbidity tends to strengthen these associations. Our data do not support MRPL19/C2ORF3 as a locus involved in reading abilities nor CMIP/ATP2C2 as genes regulating language skills.

Conclusions
We provide further support for the role of KIAA0319 and DCDC2 in contributing to reading abilities and novel evidence that the language-disorder candidate gene CMIP is also implicated in reading processes. Additionally, we present novel data to evaluate the prevalence and comorbidity of RD and SLI, and we recommend not excluding individuals with comorbid RD and SLI when designing genetic association studies for RD.

Translated title of the contributionDCDC2, KIAA0319 and CMIP are associated with reading-related traits
Original languageEnglish
Pages (from-to)237 - 245
Number of pages9
JournalBiological Psychiatry
Volume70 (3)
DOIs
Publication statusPublished - Aug 2011

Keywords

  • ALSPAC, association studies, dyslexia, language, reading abilities, specific language impairment (SLI)

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  • Projects

    EXTENSION OF RD1321 VIA IOP.

    Golding, J.

    1/02/011/02/06

    Project: Research

    Cite this

    Tom S., S., Andrew P., M., Lyn-Louise, B., Dianne F., N., Miller, LL., Anthony P., M., Golding, J., Dorothy, B., & Silvia, P. (2011). DCDC2, KIAA0319 and CMIP are associated with reading-related traits. Biological Psychiatry, 70 (3), 237 - 245. https://doi.org/10.1016/j.biopsych.2011.02.005