Projects per year
Abstract
Manmade protein design is founded on the concept that a protein with minimal evolutionary complexity is a viable scaffold for incorporating simple engineering elements responsible for function in natural proteins and enzymes. There has been significant, recent success both in fabricating manmade protein components that exhibit functional elements inspired by natural oxidoreductases, and the functional integration of this componentry with natural proteins and biochemical pathways. Here we discuss the state of the art in de novo oxidoreductase construction, focusing on the diverse manmade componentry available and how their functions might be interfaced and integrated within living organisms.
Original language | English |
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Pages (from-to) | 90-98 |
Number of pages | 9 |
Journal | Current Opinion in Chemical Biology |
Volume | 19 |
DOIs | |
Publication status | Published - Apr 2014 |
Research Groups and Themes
- Bristol BioDesign Institute
Keywords
- REACTIVITY
- synthetic biology
- PRINCIPLES
- OXIDASE
- ELECTRON-TRANSFER
- CHROMOPHORE
- HEME
- COMPUTATIONAL ENZYME DESIGN
- MAQUETTE
- BINDING
- BUNDLE
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Dive into the research topics of 'De novo protein components for oxidoreductase assembly and biological integration'. Together they form a unique fingerprint.Projects
- 1 Finished
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Assembly of Artificial Oxidoreductase Assembly
Anderson, J. L. R. (Principal Investigator)
1/09/11 → 1/09/14
Project: Research