Dearomatising cyclisation of lithiated allyl phenyl ethers: The role of an oxazoline substituent

Rebecca A. Harvey, Ol'Ga Karlubíková, Sean Parris, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)

Abstract

Treatment of 3-allyloxyphenyl oxazolines with organolithium bases leads to allyllithiums which undergo dearomatising cyclisation. The resulting dearomatised anions may be quenched with electrophiles to form partially saturated benzopyran derivatives.

Original languageEnglish
Pages (from-to)4064-4066
Number of pages3
JournalTetrahedron Letters
Volume54
Issue number31
Early online date31 May 2013
DOIs
Publication statusPublished - 31 Jul 2013

Keywords

  • Allyllithium
  • Cyclisation
  • Dearomatisation
  • Oxazoline
  • Synthesis

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