Decoupling of sleep-dependent cortical and hippocampal interactions in a neurodevelopmental model of schizophrenia

Keith Phillips, Ullrich Bartsch, Andrew McCarthy, Dale Edgar, Mark Tricklebank, Keith Wafford, Matt W Jones

Research output: Contribution to journalArticle (Academic Journal)peer-review

89 Citations (Scopus)
394 Downloads (Pure)

Abstract

Rhythmic neural network activity patterns are defining features of sleep, but interdependencies between limbic and cortical oscillations at different frequencies and their functional roles have not been fully resolved. This is particularly important given evidence linking abnormal sleep architecture and memory consolidation in psychiatric diseases. Using EEG, local field potential (LFP), and unit recordings in rats, we show that anteroposterior propagation of neocortical slow-waves coordinates timing of hippocampal ripples and prefrontal cortical spindles during NREM sleep. This coordination is selectively disrupted in a rat neurodevelopmental model of schizophrenia: fragmented NREM sleep and impaired slow-wave propagation in the model culminate in deficient ripple-spindle coordination and disrupted spike timing, potentially as a consequence of interneuronal abnormalities reflected by reduced parvalbumin expression. These data further define the interrelationships among slow-wave, spindle, and ripple events, indicating that sleep disturbances may be associated with state-dependent decoupling of hippocampal and cortical circuits in psychiatric diseases.
Original languageEnglish
Pages (from-to)526-533
Number of pages8
JournalNeuron
Volume76
Issue number3
DOIs
Publication statusPublished - 8 Nov 2012

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