Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization

Sarah J Glennie, Dominic Banda, Kate Gould, Jason Hinds, Arox Kamngona, Dean D B Everett, Neil A Williams, Robert S Heyderman

Research output: Contribution to journalArticle (Academic Journal)peer-review

30 Citations (Scopus)

Abstract

African adults infected with human immunodeficiency virus (HIV) have high rates of pneumococcal colonization and invasive disease. Here we have investigated the possibility that HIV disrupts the normal balance of pneumococcal-specific helper T cell (Th) 1/Th17 immunity to colonization, resulting in a more permissive nasopharyngeal niche.
Original languageEnglish
Pages (from-to)291-9
Number of pages9
JournalClinical Infectious Diseases
Volume56
Issue number2
DOIs
Publication statusPublished - Jan 2013

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