Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization

Sarah J Glennie; Dominic Banda; Kate Gould; Jason Hinds; Arox Kamngona; Dean D B Everett; Neil A Williams; Robert S Heyderman

doi:10.1093/cid/cis842

Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization

Sarah J Glennie, Dominic Banda, Kate Gould, Jason Hinds, Arox Kamngona, Dean D B Everett, Neil A Williams, Robert S Heyderman

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

Abstract

African adults infected with human immunodeficiency virus (HIV) have high rates of pneumococcal colonization and invasive disease. Here we have investigated the possibility that HIV disrupts the normal balance of pneumococcal-specific helper T cell (Th) 1/Th17 immunity to colonization, resulting in a more permissive nasopharyngeal niche.

Original language	English
Pages (from-to)	291-9
Number of pages	9
Journal	Clinical Infectious Diseases
Volume	56
Issue number	2
DOIs	https://doi.org/10.1093/cid/cis842
Publication status	Published - Jan 2013

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title = "Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization",

abstract = "African adults infected with human immunodeficiency virus (HIV) have high rates of pneumococcal colonization and invasive disease. Here we have investigated the possibility that HIV disrupts the normal balance of pneumococcal-specific helper T cell (Th) 1/Th17 immunity to colonization, resulting in a more permissive nasopharyngeal niche.",

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AU - Hinds, Jason

AU - Kamngona, Arox

AU - Everett, Dean D B

AU - Williams, Neil A

AU - Heyderman, Robert S

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AB - African adults infected with human immunodeficiency virus (HIV) have high rates of pneumococcal colonization and invasive disease. Here we have investigated the possibility that HIV disrupts the normal balance of pneumococcal-specific helper T cell (Th) 1/Th17 immunity to colonization, resulting in a more permissive nasopharyngeal niche.

U2 - 10.1093/cid/cis842

DO - 10.1093/cid/cis842

M3 - Article (Academic Journal)

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SN - 1537-6591

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 2

ER -

Defective pneumococcal-specific Th1 responses in HIV-infected adults precedes a loss of control of pneumococcal colonization

Abstract

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