Degenerative encephalopathy in Nova Scotia Duck Tolling Retrievers presenting with a rapid eye movement sleep behavior disorder

Emily N Barker, Louise J Dawson, Jeremy Rose, Sofie Van Meervenne, Ole Frykman, Cecilia Rhodin, Alexandra Leijon, Karen Elisabeth Soerensen, Johanna Järnegren, Gayle C Johnson, Dennis P O'Brien, Nicolas Granger

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)
352 Downloads (Pure)

Abstract

Background: Neurodegenerative diseases are a heterogeneous group of disorders characterized by loss of neurons, and are commonly associated with a genetic mutation.

Hypothesis/Objectives: To characterize the clinical and histopathological features of a novel degenerative neurological disease affecting the brain of young adult Nova Scotia Duck-Tolling Retrievers (NSDTR).

Animals: Nine, young adult, related, NSDTR were evaluated for neurological dysfunction and rapid eye movement sleep behavior disorder.

Results: Clinical signs of neurological dysfunction began between two months and five years of age, and were progressive in nature. They were characterized by episodes of marked movements during sleep, increased anxiety, noise phobia, and gait abnormalities. Magnetic resonance imaging documented symmetrical, progressively increasing, T2-weighted image intensity, predominantly within the caudate nuclei, most consistent with necrosis secondary to grey matter degeneration. Clinicopathological analysis of blood and cerebrospinal fluid, infectious disease screening and urine metabolite screening were unremarkable in most cases. Post-mortem examination of brain tissue identified symmetrical malacia of the caudate nuclei and axonal dystrophy within the brainstem and spinal cord. Genealogical analysis supports an autosomal recessive mode of inheritance.

Conclusions and Clinical Importance: A degenerative encephalopathy was identified in young adult NSDTRs that we suspect is a hereditary disease. The prognosis is guarded due to the progressive nature of the disease, which is minimally responsive to empirical treatment.
Original languageEnglish
Pages (from-to)1681–1689
Number of pages9
JournalJournal of Veterinary Internal Medicine
Volume30
Issue number5
Early online date22 Sep 2016
DOIs
Publication statusPublished - 10 Oct 2016

Keywords

  • axonopathy
  • behavioral changes
  • basal nuclei
  • familial
  • REM sleep behavior disorder

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