This paper reports a negligible-cost, open-source method for the rapid prototyping of microfluidic systems in polydimethylsiloxane (PDMS) using a 3D-printed library of click-and-connect microchannel scaffolds. In conjunction with a simple thermal bonding process, these single-extrusion thermoplastic scaffolds are designed and used to quickly configure microfluidic system negatives, for use as master molds in the fabrication of PDMS microfluidics demonstrated herein. With this technique, a 5000-piece library of mix-and-match interconnecting channel scaffolds can be printed, with a 100 µm channel width, for ~$0.50. This simple yet innovative approach could help to lower the economic barriers for lab-on-a-chip fabrication.
|Title of host publication||MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Publisher||Chemical and Biological Microsystems Society|
|Number of pages||2|
|Publication status||Published - 2020|
|Event||24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online|
Duration: 4 Oct 2020 → 9 Oct 2020
|Name||MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences|
|Conference||24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020|
|Period||4/10/20 → 9/10/20|
Bibliographical noteFunding Information:
Research supported via the Engineering and Physical Sciences Research Council (EPSRC) & Global Challenges Research Fund (GCRF) via the BristolBridge program (EP/M027546/1) with additional support from EPSRC, grant reference EP/R032696/1. Thanks also to Dr Annela Seddon, University of Bristol, for her support.
© 2020 CBMS-0001
Copyright 2020 Elsevier B.V., All rights reserved.
- Low-Cost Microfluidics